Giuseppe Sancesario


Sancesario Giuseppe Sancesario
Department of Systems Medicine
Tel: +39 06 72596002
Lab: +39 06 72596020
Fax: +39+0672596022



Born in Presicce (LE) Italy, on 17/08/1947
Graduated in Medicine in 1976 at the University of Rome “La Sapienza”, Italy;
Certified neurologist in 1980
Certified pathologist in 1992.
Post-doctoral fellow in the Department of Neuromorphology, Max-Planck-Institut fur psychiatry, Munich, Germany, from 1985 to 1986.
Tenured researcher in 1984.
Associate professor of Clinical Neurology at the Tor Vergata University of Rome in 1998.
Visiting professor in the Department of Anatomy and Neurobiology, the University of Tennessee, Memphis in 1993, 1995 e 1997.
Director of the School of Neurology, University of Rome – Tor Vergata in years 2004-2009.
Director of the “Centro Regionale Alzheimer” – Tor Vergata University Hospital in years 2006 – 2017.
President of the Italian Association of Neuropathology in years 2007-2009.
Since 1990 he is head of the Laboratory of Experimental Neuropathology in the Department of Systems Medicine at the Tor Vergata University of Rome.


Research Activity

Dr. Sancesario is a neurologist with an expertise in experimental neuropathology. Dr. Sancesario’s studies have dealt with the mechanisms of ischemic brain damage and with the efficacy of various drugs in improving the vulnerability of neurons to ischemia, using different models of ischemia in rodents and evaluating morphologically the severity of the brain damage with light and electron microscope.

Another major field of interest of dr. Sancesario has regarded the neuropathology of basal ganglia in models of extrapyramidal disorders. He has studied the plasticity of striatal and pallidal neurons in manganese-treated or 6-OHDA-lesioned rodents. He and co-workers first identified a complex dys-regulation of the second messenger system in the basal ganglia after lesion of the substantia nigra. These results provide a better knowledge of the pathogenesis of parkinsonism and levodopa induced dyskinesia, opening the way to new therapeutic approaches.

His main clinical interest has been directed to diagnosis and treatment of Alzheimers’s disease and other dementia. In particular he oriented his research  in studying the neuroanatomical correlates of the neurodegenerative processes using multimodal MRI  and in searching CSF bio-markers of the disease processes. The specific scientific activity of dr. Sancesario is documented by 160 papers on international journals with referees.


Selected Publications