Biography

Curriculum Vitae et Studiorum

Education
School of Spectroscopic Techniques, Messina, Italy.
Fellowship of the Italian Education Department for a specialization in dynamic fluorescence at the Laboratory for Fluorescence Dynamics (LFD) at the University of  Illinois in Urbana Champaign, USA.

Actual position
Since 2004 Associate Professor in Biochemistry, University, of  Rome  “Tor Vergata”

Research Activity
Scientific activity

Protein structure to function relationship:

1. conformational stability studies of proteins by equilibrium unfolding measurements;
2. kinetic measurements of the  folding/unfolding  process of metal containing proteins;
3. structural and functional behavior of monomeric and oligomeric enzymes under high pressure condition.
4. Fluorescence microscopy and spectroscopic techniques (circular dichroism, steady-state and dynamic fluorescence; rotational anisotropy)

Giampiero Mei has published more than 70 papers on international journals.

Selected Publications

• Ivanov, I., Di Venere, A., Horn, T., Scheerer, P., Nicolai, E., Stehling, S., Richter, C., Skrzypczak-Jankun, E., Mei, G., Maccarrone, M., Hartmut Kühn, H. Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity. Biophys. Acta (2011), 1811: 1001–1010 (ISSN: 1388-1981);Elsevier Science Publishers, Amsterdam, The Netherlands.

• Ivanov, I., Shang, W., Toledo, L., Masgrau, L., I. Svergun, D. I., Stehling, S., Go´mez, H., Di Venere, A., Mei, G., Lluch, J. M., Skrzypczak-Jankun, E., Gonza´lez-Lafont, A., and Kuhn, H. Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: A key to allosteric behavior of this class of enzymes? Proteins (2012), 80 (3): 703-712.

• Patriarca, A., Polticelli, F., Piro, M.C., Sinibaldi, F., Mei, G., Bari, M., Santucci, R., and Fiorucci, L. Conversion of cytochrome c into a peroxidase: Inhibitory mechanisms and implication for neurodegenerative diseases; Biochem. Biophys. (2012), 522: 62–69 (ISSN: 0003-9861)

• Di Venere, A., Dainese, E., Fezza, F., Angelucci, B.C., Rosato, N., Cravatt, B.F., Finazzi-Agrò, A., Mei, G., and Maccarrone, M. Rat and human fatty acid amide hydrolases: Overt similarities and hidden differences. Biophys. Acta (2012), 1821: 1425–1433 (ISSN: 1388-1981); Elsevier Science Publishers, Amsterdam, The Netherlands.

• Di Venere, A., Horn, T., Stehling, S., Mei, G., Masgrau, L., González-Lafont, A., Kühn, H., and Ivanov, I. Role of Arg403 for thermostability and catalytic activity of rabbit 12/15-lipoxygenase. Biophys. Acta (2013), 1831: 1079–1088 (ISSN: 1388-1981)

• Varriale, A., Marabotti, A., Mei, G., Staiano, M. and D’Auria, Fluorescence Correlation Spectroscopy and Molecular Dynamics simulations to study the structural features of proteins. Plos ONE (2013), 8(6): e64840. (ISSN: 1932-6203)

• Di Nardo, G., Breitner, M., Sadeghi, S.J., Castrignano, S., Mei, G., Di Venere, A., Nicolai, E., Allegra, P., and Gilardi, G. Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy; Plos ONE (2013), 8(12): e82118. (ISSN: 1932-6203)

• Di Venere, A., Nicolai, E., Ivanov, I., Dainese, E., Adel, S., Angelucci, B.C., Hartmut Kuhn, H., Maccarrone, M., Mei, G. Probing conformational changes in lipoxygenases upon membrane binding: Fine-tuning by the active site inhibitor ETYA; Biophys. Acta (2014), 1841: 1–10 (ISSN: 1388-1981)

• Tasdighian S., Di Paola, L., De Ruvo, M., Paci, P., Santoni, , Palumbo, P., Mei, G., Di Venere,A. and Giuliani, A. Modules Identification in Protein Structures: The Topological and Geometrical Solutions; Chem. Inf. Model. (2014), 54: 159-168 (ISSN: 1549-9596)

• Brunelli, R., De Spirito, M., Mei, G., Papi, M., Perrone, G., Stefanutti, C. and Parasassi, T. Misfolding of apoprotein B-100, LDL aggregation and 17-b-estradiol atherogenesis; Current Medicinal Chemistry (2014), 21:2276-2283 (ISSN: 0929-8673)

• De Luca, A., Mei, G., Rosato, N., Nicolai, E., Federici, L., Palumbo, C., Pastore, A., Serra, M., and Caccuri, A.M., The fine-tuning of TRAF2–GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex; Cell Death and Disease (2014) 5: e1015 (ISSN:  2041-4889)

• Ceccarelli, A., Di Venere, Nicolai, E., A., De Luca, A., Minicozzi, V., Rosato, N., Caccuri, A.M., and Mei, G. TNFR-associated factor-2 (TRAF2): not only a trimer; Biochemistry (2015) 54(40): 6153-6161 (ISSN: 0006-2960)

• Di Paola, L., Mei, G., Di Venere,A. and Giuliani, A. Exploring the stability of dimers through protein structure topology; Current Protein and Peptide Science (2016) 17: 30-36 (ISSN: 1389-2037)

• Ceccarelli, A., Di Venere, Nicolai, E., A., De Luca, A., Rosato, N., Gratton, E., Mei, G and Caccuri, A.M. New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains; Biophys. Acta (2017), 1862: 813–822 (ISSN: 1388-1981)

• Di Venere, A., Nicolai, E., Sinibaldi, F., Di Pierro, D., Caccuri, A.M., Mei, G. Studying the TRAF2 binding to model membranes: the roles of subunits dissociation; Biotechnol. Appl. Biochem. (2018), 65: 38–45 (ISSN: 0885-4513)

Teaching – link to Didattica web