Biography

Curriculum Vitae et Studiorum

Research Activity

The main interest are focused on the studies of the risk factors of workers exposed to potential toxicants.

He worked in the organization of multidisciplinary research groups on
a) effect of electromagnetic fields on “in vitro” systems, with particular regards to cell coltures
b) impact on public health of nanotecnnologies development. In particular, his research group has performed several experimental works on in vitro toxic effects of nanoparticles. He has carried out research in the field of Industrial and Environmental Toxicology that has been aimed at developing biomarkers of exposure, internal dose and early effects on critical organs and their application on groups of workers occupationally exposed to xenobiotics. The researches have been characterized by a multidisciplinary approach, including analytical chemistry and molecular biology methods, using both experimental and epidemiological evaluations, from mechanistic studies to risk assessment in specific groups of exposed workers. He was local coordinator for the National Project MIUR2006069554 “Interaction of novel nanoparticulate materials with biological systems: testing models for human health risk assessmen” and is collaborating to EU-funded NANORETOX (7thFP). He is member of the National Committee for the Occupational Safety of Nanomaterials (ISPESL) and charter member of the Nanoparticles Italian Research Association, aimed at promoting scientific research on nanoparticles toxicology and safety. Member of the Network of excellence NanoimpactNet.

He also studied the etiopathogenic role of helicobacter pylori on gastric diseases, and the asymptomatic transmission hepatitis C virus infection.

Other research interests:
Risk factors for cardiovascular disease – job disaffection and burn out – stress related disease – VDT as an occupational risk factor – Epidemiology of dust-related disorders.

Selected Publications

• Campagnolo L, Massimiani M, Vecchione L, Piccirilli D, Toschi N, Magrini A, Bonanno E, Scimeca M, Castagnozzi L, Buonanno G, Stabile L, Cubadda F, Aureli F, Fokkens PH, Kreyling WG, Cassee FR, Pietroiusti A. Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus. Nanotoxicology. 2017 Jun;11(5):687-698. doi: 10.1080/17435390.2017.1343875. Epub 2017 Jul 7.
• Grana M, Toschi N, Vicentini L, Pietroiusti A, Magrini A. Exposure to ultrafine particles in different transport modes in the city of Rome. Environ Pollut. 2017 Sep;228:201-210. doi: 0.1016/j.envpol.2017.05.032. Epub 2017 May 22.
• Toschi N, Ciulli S, Diciotti S, Duggento A, Guerrisi M, Magrini A, Campagnolo L, Pietroiusti A. Forecasting nanoparticle toxicity using nonlinear predictive regressor learning systems Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:137-140. doi: 10.1109/EMBC.2016.7590659.
• Cremaschini M, Moretti R, Valoti M, Barbaglio G, Arnoldi M, Bigoni F, Guaschi E, Merisi F, Passera P, Rebba A, Signori M, Tomio M, Baldasseroni A, Carrer P, Costa G, Dal Cason L, De Santa A, Gelatti U, Gili C, Magrini A, Masanotti G, Mosconi G, Pagliaro G, Ramistella E, Ronchin M, Riboldi L, Sartorelli P, Scafato E, Serra A, Tinghino B, Valente P, Valetto MR, Vigna L. Delphi consensus on the monitoring tools of main individual risk factors for chronic diseases by the company doctor. Med Lav. 2017 Feb 15;108(1):24-32. doi: 10.23749/mdl.v108i1.5476. Italian.
• Magrini A, Coppeta L, Somma G, Neri A, Gentili S, Fiocco G, Pietroiusti A. Risk of tuberculosis in healthcare workers: risk assessment and medical surveillance. Ig Sanita Pubbl. 2016 Mar-Apr;72(2):137-43.
• Polimeni M, Gulino GR, Gazzano E, Kopecka J, Marucco A, Fenoglio I, Cesano F, Campagnolo L, Magrini A, Pietroiusti A, Ghigo D, Aldieri E. Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway. Part Fibre Toxicol. 2016 Jun 1;13(1):27. doi: 10.1186/s12989-016-0138-4.
• Bottini M, Bhattacharya K, Fadeel B, Magrini A, Bottini N, Rosato N.  Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. Nanomedicine. 2016 Feb;12(2):255-68. doi: 10.1016/j.nano.2015.09.013. Epub 2015 Dec 18. Review.
• Pietroiusti A, Magrini A, Campagnolo L. New frontiers in nanotoxicology: Gut microbiota/microbiome-mediated effects of engineered nanomaterials. Toxicol Appl Pharmacol. 2016 May 15;299:90-5. doi: 10.1016/j.taap.2015.12.017. Epub 2015 Dec 23.
• Bottini M, Magrini A, Fadeel B, Rosato N. Tackling chondrocyte hypertrophy with multifunctional nanoparticles. Gene Ther. 2016 Apr 14. doi: 10.1038/gt.2016.33. [Epub ahead of print] No abstract available.
• Gloria-Bottini F, Ammendola M, Saccucci P, Neri A, Magrini A, Bottini E. The effect of ACP1, ADA6 and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis. Arch Gynecol Obstet. 2016 Feb;293(2):399-402. doi: 10.1007/s00404-015-3827-6. Epub 2015 Jul 28.
• Grana M, Vicentini L, Pietroiusti A, Magrini A. Ultrafine particle emissions from laser printers. G Ital Med Lav Ergon. 2015 Jul-Sep;37(3):135-43. Italian.
• Salerno S, Dimitri L, Livigni L, Magrini A, Talamanca I.F. Mental health in the hospital. Analysis of conditions of risk by department, age and gender, for the creation of best practices for the health of nurses. G Ital Med Lav Ergon. 2015 Jan-Mar;37(1):46-55. Italian.
• Magrini A, Pelagalli MF, Pietroiusti A, Livigni L, Guidi S, Moscatelli M, Mascioli M, D’Orsi F, Zolla A, Bagnara S. In-depth assessment of work-related stress in a major company undergoing restructuring]. Med Lav. 2015 Jul 8;106(4):250-60. Italian.
• Pietroiusti A, Magrini A. Engineered nanoparticles at the workplace: current knowledge about workers’ risk. Occup Med (Lond). 2015 Mar;65(2):171-3. doi: 10.1093/occmed/kqu194. No abstract available.
• Sangiuolo F, Puxeddu E, Pezzuto G, Cavalli F, Longo G, Comandini A, Di Pierro D, Pallante M, Sergiacomi G, Simonetti G, Zompatori M, Orlandi A, Magrini A, Amicosante M, Mariani F, Losi M, Fraboni D, Bisetti A, Saltini C. HFE gene variants and iron-induced oxygen radical generation in idiopathic pulmonary fibrosis. Eur Respir J. 2015 Feb;45(2):483-90. doi: 10.1183/09031936.00104814. Epub 2014 Dec 10.
• Magnavita N, De Lorenzo G, Gallo M, Garbarino S, Goggiamani A, Janiri L, Messineo A, Miggiano G, Pichini S, Porpora A, Poscia A, Sacco A, Spagnolo AG, Vogel L, Ciprani F, Deidda B, Fenudi L, Magrini A, Morini L, Moscato U, Proietti AR, Ranalletta D, Santoro PE, Soave PM, Stanzani C, Bottaro LC, Ricciardi W, Gruppo di studio Lavoratori Rischiosi per gli Altri .Alcohol and work. Consensus Document of the La.R.A. (Workers representing a risk for others) group. Med Lav. 2014 Nov 13;105 Suppl 1:3-68. Italian.
• Magrini A, Grana M, Vicentini L. Chemical, physical and biological risks in law enforcement. G Ital Med Lav Ergon. 2014 Oct-Dec;36(4):382-91. Review. Spanish.
• Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26.
• Serone E, Daleno C, Principi N, Porretti L, Iacoacci V, Gargioli C, Magrini A, Massoud R, D’Addabbo P, Cattalini M, Giambra V, Plebani A, Esposito S, Frezza D.  The change in Ig regulation from children to adults disconnects the correlation with the 3’RR hs1.2 polymorphism. BMC Immunol. 2014 Nov 13;15:45. doi: 10.1186/s12865-014-0045-0.
• Gloria-Bottini F, Saccucci P, Meloni GF, Manca-Bitti ML, Coppeta L, Neri A, Magrini A, Egidio B. Study of factors influencing susceptibility and age at onset of type 1 diabetes: A review of data from Continental Italy and Sardinia. World J Diabetes. 2014 Aug 15;5(4):557-61. doi: 10.4239/wjd.v5.i4.557.
• Gloria-Bottini F, Saccucci P, Manca-Bitti ML, Rapini N, Verrotti A, Neri A, Magrini A, Bottini E. Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype. Diabetes Res Clin Pract. 2014 Oct;106(1):e7-9. doi: 10.1016/j.diabres.2014.07.022. Epub 2014 Jul 29.
• Pietroiusti A, Magrini A. Engineered nanoparticles at the workplace: current knowledge about workers’ risk. Occup Med (Lond). 2014 Jul;64(5):319-30. doi: 10.1093/occmed/kqu051. Review. Erratum in: Occup Med (Lond). 2015 Mar;65(2):171-3.
• Masala S, Magrini A, Taglieri A, Nano G, Chiaravalloti A, Calabria E, Di Trapano R, Pietroiusti A, Simonetti G. Chronic obstructive pulmonary disease (COPD) patients with osteoporotic vertebral compression fractures (OVCFs): improvement of pulmonary function after percutaneous vertebroplasty (VTP). Eur Radiol. 2014 Jul;24(7):1577-85. doi: 10.1007/s00330-014-3165-2. Epub 2014 Apr 18.
• Bottini M, Sacchetti C, Pietroiusti A, Bellucci S, Magrini A, Rosato N, Bottini N. Targeted nanodrugs for cancer therapy: prospects and challenges. J Nanosci Nanotechnol. 2014 Jan;14(1):98-114. Review.
• Saccucci P, Binczak-Kuleta A, Banci M, Krzysztalowska M, Dofcaci A, Safranow K, Magrini A, Loniewska B, Kornacewicz-Jach Z, Chlubek D, Bottini E, Ciechanowicz A, Gloria-Bottini F. Coronary artery disease. A study of three polymorphic sites of adenosine deaminase gene. Acta Cardiol. 2014 Feb;69(1):39-44.
• Jaccoud C, Magrini A. Regulation of solid waste management at Brazilian ports: analysis and proposals for Brazil in light of the European experience. Mar Pollut Bull. 2014 Feb 15;79(1-2):245-53. doi: 10.1016/j.marpolbul.2013.12.006. Epub 2013 Dec 22.
• Campagnolo L, Massimiani M, Palmieri G, Bernardini R, Sacchetti C, Bergamaschi A, Vecchione L, Magrini A, Bottini M, Pietroiusti A. Biodistribution and toxicity of pegylated single wall carbon nanotubes in pregnant mice.  Part Fibre Toxicol. 2013 Jun 6;10:21. doi: 10.1186/1743-8977-10-21.
• Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjug Chem. 2013 Jun 19;24(6):852-8. doi: 10.1021/bc400070q. Epub 2013 May 22.
• Campagnolo L, Fenoglio I, Massimiani M, Magrini A, Pietroiusti A. Screening of nanoparticle embryotoxicity using embryonic stem cells. Methods Mol Biol. 2013;1058:49-60. doi: 10.1007/7651_2013_11.
• Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance. ACS Nano. 2013 Mar 26;7(3):1974-89. doi: 10.1021/nn400409h. Epub 2013 Feb 28.

Teaching – link to Didattica web