Alessandro Desideri

Profile

foto_scheda-ADesideri Alessandro Desideri
Email
desideri@uniroma2.it
Office/Location
Dept. Biology
Tel: +39 06 72594376
Fax: +39 06 2022798

Biography

Biography

Work in progress

Research

Research Activity

Work in progress

Publications

Selected Publications

  • Raniolo, S., Vindigni, G., Unida, V., Ottaviani, A., Romano, E., Desideri, A., et al. (2018). Entry, fate and degradation of DNA nanocages in mammalian cells: a matter of receptors. NANOSCALE, 10(25), 12078-12086.  
  • Cardamone, F., Falconi, M., & Desideri, A. (2018). Molecular dynamics characterization of the SAMHD1 Aicardi–Goutières Arg145Gln mutant: structural determinants for the impaired tetramerization. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 32(5), 623-632.  
  • Raniolo, S., Vindigni, G., Ottaviani, A., Unida, V., Iacovelli, F., Manetto, A., et al. (2018). Selective targeting and degradation of doxorubicin-loaded folate-functionalized DNA nanocages. NANOMEDICINE, 14(4), 1181-1190.  
  • Velásquez, A., Ribeiro, W.c., Venn, V., Castelli, S., Santoro, M., de Assis, R.p., et al. (2017). Efficacy of a Binuclear Cyclopalladated Compound Therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis and its inhibitory effect on Topoisomerase 1B. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AAC.00688-17.  
  • Iacovelli, F., Idili, A., Benincasa, A., Mariottini, D., Ottaviani, A., Falconi, M., et al. (2017). Simulative and experimental characterization of a pH-dependent clamp-like DNA triple-helix nanoswitch. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 139(15), 5321-5329.  
  • Cardamone, F., Iacovelli, F., Chillemi, G., Falconi, M., & Desideri, A. (2017). A molecular dynamics simulation study decodes the early stage of the disassembly process abolishing the human SAMHD1 function. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 31(5), 497-505.  
  • Cardamone, F., Pizzi, S., Iacovelli, F., Falconi, M., & Desideri, A. (2017). Virtual Screening for the Development of Dual-Inhibitors Targeting Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1. CURRENT DRUG TARGETS, 18, 544-555.
  • Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dotsch, V., Levine, A.j., et al. (2017). Structural evolution and dynamics of the p53 proteins. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 7(4), a028308.  
  • De Grandis, R.A., de Camargo, M.S., da Silva, M.M., Lopes, E.O., Padilha, E.C., Resende, F.A., et al. (2017). Human topoisomerase inhibition and DNA/BSA binding of Ru(II)–SCAR complexes as potential anticancer candidates for oral application. BIOMETALS, 30(3), 321-334.  
  • Franch, O., Iacovelli, F., Falconi, M., Juul, S., Ottaviani, A., Benvenuti, C., et al. (2016). DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family. NANOSCALE, 8(27), 13333-13341.
  • Vindigni, G., Raniolo, S., Ottaviani, A., Falconi, M., Franch, O., Knudsen, B.r., et al. (2016). Receptor-Mediated Entry of Pristine Octahedral DNA Nanocages in Mammalian Cells. ACS NANO.  
  • Alves, C., Iacovelli, F., Falconi, M., Cardamone, F., Morozzo Della Rocca, B., de Oliveira, C., et al. (2016). A Simple and Fast Semiautomatic Procedure for the Atomistic Modeling of Complex DNA Polyhedra. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 56(5), 941-949.
  • Errico, V., Molinaro, R., Gargioli, C., Ferranti, F., Dinescu, M., Cannata, S., et al. (2016). Cells microenvironment engineering multiphoton absorption for muscle regeneration optimization. Paper presented at BIODEVICES 2016 – 9th International Conference on Biomedical Electronics and Devices,.  
  • Cicero, D.O., Di Marino, S., Dinallo, V., Pero, M., Summa, V., Desideri, A., et al. (2016). A Small Sided Game session effects salivary metabolic levels in young soccer players. BIOMEDICAL SPECTROSCOPY AND IMAGING.  
  • D’Abramo, M., Besker, N., Desideri, A., Levine, A.j., Melino, G., & Chillemi, G. (2016). The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain. ONCOGENE, 35(25), 3272-3281.  
  • Iacovelli, F., Falconi, M., Knudsen, B.r., & Desideri, A. (2016). Comparative simulative analysis of single and double stranded truncated octahedral DNA nanocages. RSC ADVANCES, 6(42), 35160-35166.
  • Vutey, V., Castelli, S., D’Annessa, I., Samia, L., Souza-Fagundes, E.m., Beraldo, H., et al. (2016). Human topoisomerase IB is a target of a thiosemicarbazone copper(II) complex. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 606, 34-40.
  • Jahan, Z., Cerreto, M., Aversa, G., Rufini, S., Desideri, A., & Giovanetti, A. (2015). Role of Topoisomerase IB on Damage Induced by Ionizing Radiation. In K P Mishra Editor (a cura di), Biological Responses, Monitoring and Protection from Radiation Exposure. Hauppauge NY 11788-3619 : Nova publishers.  
  • Biocca, S., & Desideri, A. (2015). The Potential of Nucleic Acid-Based Nanoparticles for Biomedical Application. NANO LIFE, 05(04), 1541004.  
  • Biocca, S., Iacovelli, F., Matarazzo, S., Vindigni, G., Oteri, F., Desideri, A., et al. (2015). Molecular mechanism of statin-mediated LOX-1 inhibition. CELL CYCLE, 14(10), 1583-1595.  
  • Capobianchi, M.r., Gruber, C., Carletti, F., Meschi, S., Castilletti, C., Vairo, F., et al. (2015). Molecular signature of the Ebola virus associated with the fishermen community outbreak in Aberdeen, Sierra Leone, in February 2015. GENOME ANNOUNCEMENTS, 3(5), e01093-15.  
  • Castilletti, C., Carletti, F., Gruber, C., Bordi, L., Lalle, E., Quartu, S., et al. (2015). Molecular characterization of the first Ebola virus isolated in Italy, from a health care worker repatriated from Sierra Leone. GENOME ANNOUNCEMENTS, 3(3), e00639-15.  
  • Leon, I.e., Cadavid-Vargas, J.f., Tiscornia, I., Porro, V., Castelli, S., Katkar, P., et al. (2015). Oxidovanadium(IV) complexes with chrysin and silibinin: Anticancer activity and mechanisms of action in a human colon adenocarcinoma model. JBIC, 20(7), 1175-1191.  
  • Molinaro, R., Rufini S, Saggio, G., Errico, V., Ferranti, F., & Desideri, A. (2015). Role of electro-mechanical stress on the switch proliferation/differentiation on C2C12 cells. In Proceedings of Biophysics@Rome 2015.
  • Vieira, S., Castelli, S., Falconi, M., Takarada, J., Fiorillo, G., Buzzetti, F., et al. (2015). Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 77, 68-75.  
  • Wang, Z., D’Annessa, I., Tesauro, C., Croce, S., Ottaviani, A., Fiorani, P., et al. (2015). Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1854(8), 860-868.  
  • Zuccaro, L., Krieg, J., Desideri, A., Kern, K., & Balasubramanian, K. (2015). Tuning the isoelectric point of graphene by electrochemical functionalization. SCIENTIFIC REPORTS, 5(1), 11794.  
  • Zuccaro, L., Tesauro, C., Kurkina, T., Fiorani, P., Yu, H.k., Knudsen, B.r., et al. (2015). Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene. ACS NANO, 9(11), 11166-11176.
  • Chandramouli, B., Chillemi, G., & Desideri, A. (2014). Structural dynamics of V3 loop in a trimeric ambiance, a molecular dynamics study on gp120-CD4 trimeric mimic. JOURNAL OF STRUCTURAL BIOLOGY, 186(1), 132-140.  
  • D’Annessa, I., Coletta, A., & Desideri, A. (2014). Geometrical constraints limiting the poly(ADP-ribose) conformation investigated by molecular dynamics simulation. BIOPOLYMERS, 101, 78-86.
  • D’Annessa, I., Coletta, A., Sutthibutpong, T., Mitchell, J., Chillemi, G., Harris, S., et al. (2014). Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein-DNA binding site. NUCLEIC ACIDS RESEARCH.  
  • Iacovelli, F., Alves, C., Falconi, M., Oteri, F., de Oliveira, C., & Desideri, A. (2014). Influence of the single-strand linker composition on the structural/dynamical properties of a truncated octahedral DNA nano-cage family. BIOPOLYMERS, 101(10), 992-999.
  • Katkar, P., Coletta, A., Castelli, S., Sabino, G.L., Couto, R.A., Ferreira, A.M., et al. (2014). Effect of oxindolimine copper(II) and zinc(II) complexes on human topoisomerase I activity. METALLOMICS, 6(1), 117-125.
  • Saggio, G., Bianchi, L., Castelli, S., Santucci, M.B., Fraziano, M., & Desideri, A. (2014). In vitro analysis of pyrogenicity and cytotoxicity profiles of flex sensors to be used to sense human joint postures. SENSORS, 14(7), 11672-11681.  
  • Tesauro, C., Graziani, G., Arnò, B., Zuccaro, L., Muzi, A., D’Annessa, I., et al. (2014). Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 33(1), 71.  
  • Tesauro, C., Graziani, G., Arnò, B., Zuccaro, L., Muzi, A., D’Annessa, I., et al. (2014). Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 33(1), 71.  
  • Zuccaro, L., Tesauro, C., Cerroni, B., Ottaviani, A., Knudsen, B.R., Balasubramanian, K., et al. (2014). Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads. ANALYTICAL BIOCHEMISTRY, 451, 42-44.  
  • Biocca, S., Arcangeli, T., Tagliaferri, E., Testa, B., Vindigni, G., Oteri, F., et al. (2013). Simulative and experimental investigation on the cleavage site that generates the soluble human LOX-1. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 540(1-2), 9-18.
  • Juul, S., Iacovelli, F., Falconi, M., Kragh, S., Christensen, B., Frøhlich, R., et al. (2013). Temperature-controlled encapsulation and release of an active enzyme in the cavity of a self-assembled DNA nanocage. ACS NANO, 7(11), 9724-9734.  
  • Jensen, P., Falconi, M., Kristoffersen, E., Simonsen, A., Cifuentes, J., Marcussen, L., et al. (2013). Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor. BIOSENSORS & BIOELECTRONICS, 48, 230-237.  
  • Tesauro, C., Morozzo Della Rocca, B., Ottaviani, A., Coletta, A., Zuccaro, L., Arnò, B., et al. (2013). Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico. MOLECULAR CANCER, 12(1), 100-100.
  • Falconi, M., Iacovelli, F., & Desideri, A. (2013). A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils. JOURNAL OF MOLECULAR MODELING, 19(9), 3695-3704.
  • Falconi, M., Ciccone, S., D’Arrigo, P., Viani, F., Sorge, R., Novelli, G., et al. (2013). Design of a novel LOX-1 receptor antagonist mimicking the natural substrate. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 438(2), 340-345.
  • Castelli, S., Katkar, P., Vassallo, O., Falconi, M., Linder, S., & Desideri, A. (2013). A natural anticancer agent thaspine targets human topoisomerase IB. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 13(2), 356-363.  
  • Castelli, S., Stella, L., Petrarca, P., Battistoni, A., Desideri, A., & Falconi, M. (2013). Zinc ion coordination as a modulating factor of the ZnuA histidine-rich loop flexibility: a molecular modeling and fluorescence spectroscopy study. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(2), 769-773.  
  • Arnò, B., Coletta, A., Tesauro, C., Zuccaro, L., Fiorani, P., Lentini, S., et al. (2013). A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism. BIOSCIENCE REPORTS, 33(2), 269.  
  • Arnò, B., D’Annessa, I., Tesauro, C., Zuccaro, L., Ottaviani, A., Knudsen, B., et al. (2013). Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant. PLOS ONE.
  • Chillemi, G., Davidovich, P., D’Abramo, M., Mametnabiev, T., Garabadzhiu, A.V., Desideri, A., et al. (2013). Molecular dynamics of the full-length p53 monomer. CELL CYCLE, 12(18), 3098-3108.
  • Coletta, A., & Desideri, A. (2013). Role of the protein in the DNA sequence specificity of the cleavage site stabilized by the camptothecin topoisomerase IB inhibitor: a metadynamics study. NUCLEIC ACIDS RESEARCH, 41(22), 9977-9986.
  •  Coletta, A., Castelli, S., Chillemi, G., Sanna, N., Cushman, M., Pommier, Y., et al. (2013). Solvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probes. PLOS ONE.
  •  D’Annessa, I., Tesauro, C., Wang, Z., Arnò, B., Zuccaro, L., Fiorani, P., et al. (2013). The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834(12), 2712-2721.
  • Jahan, Z., Castelli, S., Aversa, G., Rufini, S., Desideri, A., & Giovanetti, A. (2013). Role of human topoisomerase IB on ionizing radiation induced damage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 432(3), 545-548.
  • Prada, C.F., Alvarez-Velilla, R., Balaña-Fouce, R., Prieto, C., Calvo-Alvarez, E., Escudero-Martínez, J.M., et al. (2013). Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect. BIOCHEMICAL PHARMACOLOGY, 85, 1433-1440.
  • Juul, S., Nielsen, C.J., Labouriau, R., Roy, A., Tesauro, C., Jensen, P.W., et al. (2012). Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement. ACS NANO, 6(12), 10676-10683.
  • Castelli, S., Coletta, A., D’Annessa, I., Fiorani, P., Tesauro, C., & Desideri, A. (2012). Interaction between natural compounds and human topoisomerase I. BIOLOGICAL CHEMISTRY, 393(11), 1327-1340.
  • Chandramouli, B., Chillemi, G., Abbate, I., Capobianchi, M., Rozera, G., & Desideri, A. (2012). Importance of V3 loop flexibility and net charge in the context of co-receptor recognition. A molecular dynamics study on HIV gp120. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 29(5), 879-891.
  •  Chillemi, G., De Santis, S., Falconi, M., Mancini, G., Migliorati, V., Battistoni, A., et al. (2012). Carbon monoxide binding to the heme group at the dimeric interface modulates structure and copper accessibility in the Cu,Zn superoxide dismutase from Haemophilus ducreyi: in silico and in vitro evidences. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 30(3), 269-279.
  • D’Annessa, I., Tesauro, C., Fiorani, P., Chillemi, G., Castelli, S., Vassallo, O., et al. (2012). Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin. JOURNAL OF AMINO ACIDS, 2012, 206083-206083.
  • Garcia, P.S., Chieppa, G., Desideri, A., Cannata, S., Romano, E., Luly, P., et al. (2012). Sticholysin II: A pore-forming toxin as a probe to recognize sphingomyelin in artificial and cellular membranes. TOXICON, 60(5), 724-733.
  • Mancini, G., D’Annessa, I., Coletta, A., Chillemi, G., Pommier, Y., Cushman, M., et al. (2012). Binding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interaction. PLOS ONE, 7(12), e51354-e51354.
  •  Tesauro, C., Juul, S., Arnò, B., Nielsen, C., Fiorani, P., Frøhlich, R., et al. (2012). Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification. In Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE (pp. 2416-2419). IEEE.  
  • Falconi, M., Oteri, F., Di Palma, F., Pandey, S., Battistoni, A., & Desideri, A. (2011). Structural-dynamical investigation of the ZnuA histidine-rich loop: involvement in zinc management and transport. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 25(2), 181-194.  
  • Abbate, I., Vlassi, C., Rozera, G., Bruselles, A., Bartolini, B., Giombini, E., et al. (2011). Detection of quasispecies variants predicted to use CXCR4 by ultra-deep pyrosequencing during early HIV infection. AIDS, 25(5), 611-617.  
  • Ciccacci, C., Falconi, M., Paolillo, N., Oteri, F., Forte, V., Novelli, G., et al. (2011). Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis in a warfarin hypersensitive patient. PHARMACOGENETICS AND GENOMICS, 21(6), 344-346.  
  • Galbiati, A., Rocca, B., Tabolacci, C., Beninati, S., Desideri, A., & Paradossi, G. (2011). PVA engineered microcapsules for targeted delivery of camptothecin to HeLa cells. MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS, 31(8), 1653-1659.  
  • Galbiati, A., Tabolacci, C., Morozzo della Rocca, B., Mattioli, P., Beninati, S., Paradossi, G., et al. (2011). Targeting Tumor Cells through Chitosan-Folate Modified Microcapsules Loaded with Camptothecin. BIOCONJUGATE CHEMISTRY, 22(6), 1066-1072.  
  • Oteri, F., Falconi, M., Chillemi, G., Andersen, F.F., Oliveira, C., Pedersen, J.P., et al. (2011). Simulative Analysis of a Truncated Octahedral DNA Nanocage Family Indicates the Single-Stranded Thymidine Linkers as the Major Player for the Conformational Variability. JOURNAL OF PHYSICAL CHEMISTRY. C, 115(34), 16819-16827.  
  • D’Angelo, P., Zitolo, A., Pacello, F., Mancini, G., Proux, O., Hazemann, J.L., et al. (2010). Fe-heme structure in Cu, Zn superoxide dismutase from Haemophilus ducreyi by X-ray absorption spectroscopy. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 498(1), 43-49.  
  • Amati, F., Diano, L., Campagnolo, L., Vecchione, L., Cipollone, D., Bueno, S., et al. (2010). Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist. BMC GENOMICS, 11(1), 497.  
  • Balasubramanian, C., Prasad Ojha, R., Maiti, S., & Desideri, A. (2010). Sampling the structure of the noncanonical lin-4:lin-14 microRNA:mRNA complex by molecular dynamics simulations. JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, 114, 16443-16449.
  • Chillemi, G., Coletta, A., Mancini, G., & Desideri, A. (2010). An amber compatible molecular mechanics force field for the anticancer drug topotecan. THEORETICAL CHEMISTRY ACCOUNTS, 127(4), 293-302.
  • Coletta, A., Morozzo Della Rocca, B., Jaisankar, P., Majumder, H., Chillemi, G., Sanna, N., et al. (2010). Assignment of UV-vis spectrum of (3,3′)-diindolylmethane, a Leishmania donovani topoisomerase IB inhibitor and a candidate DNA minor groove binder. JOURNAL OF PHYSICAL CHEMISTRY. A, MOLECULES, SPECTROSCOPY, KINETICS, ENVIRONMENT, & GENERAL THEORY, 114(26), 7121-7126.  
  • Mancini, G., D’Annessa, I., Coletta, A., Sanna, N., Chillemi, G., & Desideri, A. (2010). Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I – DNA complex. PLOS ONE, 5(6), e10934.  
  • Morozzo della Rocca, B., Smith, C., Tesauro, C., Desideri, A., & Weightman, P. (2010). Adsorption of the cysteine–tryptophan dipeptide at the Au(110)/liquid interface studied using reflection anisotropy spectroscopy. SURFACE SCIENCE, 604(23-24), 2170-2176.  
  • Pinto-Oliveira, C., Juul, S., Lærke Jørgensen, H., Knudsen, B., Tordrup, D., Oteri, F., et al. (2010). Structure of nano-Scale Truncated Octahedral DNA Cages: Variation of Single-stranded Linker Regions and Influence on Assembly Yields. ACS NANO, 4(3), 1367-1376.
  • Tesauro, C., Fiorani, P., D’Annessa, I., Chillemi, G., Turchi, G., & Desideri, A. (2010). Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I. BIOCHEMICAL JOURNAL, 425(3), 531-539.
  • Zazza, C., Coletta, A., Sanna, N., Mancini, G., & Desideri, A. (2010). Solvent Effects on the Valence UV-Vis Absorption Spectra of Topotecan Anticancer Drug in Aqueous Solution at Room Temperature: A Nanoseconds Time-scale TD-DFT/MD Computational Study. JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, 114(20), 6770-6778.
  • D’annessa, I., Chillemi, G., & Desideri, A. (2009). Structural-dynamical properties of the Deinococcus radiodurans topoisomerase IB in absence of DNA: correlation with the human enzyme. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 27(3), 307-318.
  • Bruzzese, F., Rocco, M., Castelli, S., Di Gennaro, E., Desideri, A., & Budillon, A. (2009). Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis. MOLECULAR CANCER THERAPEUTICS, 8(11), 3075-3087.
  • Fiorani, P., Tesauro, C., Mancini, G., Chillemi, G., D’Annessa, I., Graziani, G., et al. (2009). Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. NUCLEIC ACIDS RESEARCH, 37(20), 6849-6858.  
  • Sanna, N., Chillemi, G., Gontrani, L., Grandi, A., Mancini, G., Castelli, S., et al. (2009). UV-vis spectra of the anticancer camptothecin family drugs in aqueous solution: specific spectroscopic signatures unraveled by a combined computational and experimental study. JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, 113(16), 5369-5375.
  •  Ammendola, S., Lembo, A., Battistoni, A., Tagliatesta, P., Ghisalberti, C., & Desideri, A. (2009). 10-Undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability. FEMS MICROBIOLOGY LETTERS, 294(1), 61-67.  
  • Biocca, S., Falconi, M., Filesi, I., Baldini, F., Vecchione, L., Mango, R., et al. (2009). Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity. PLOS ONE, 4(2), 4648.  
  • Castelli, S., Campagna, A., Vassallo, O., Tesauro, C., Fiorani, P., Tagliatesta, P., et al. (2009). Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 486(2), 103-110.  
  • Falconi, M., Oteri, F., Chillemi, G., Andersen, F., Tordrup, D., Oliveira, C., et al. (2009). Deciphering the Structural Properties That Confer Stability to a DNA Nanocage. ACS NANO, 3(7), 1813-1822.  
  • Conte, C., Gambardella, S., Bulli, C., Rinaldi, F., Di Marino, D., Falconi, M., et al. (2008). Screening of EDA1 gene in X-linked anhidrotic ectodermal dysplasia using DHPLC: identification of 14 novel mutations in Italian patients. GENETIC TESTING, 12(3), 437-442.  
  • Lauria, G., Sanchez, P., Della Rocca, B., Pierri, C., Polizio, F., Stipani, I., et al. (2008). Structural-dynamical properties of the transmembrane segment VI of the mitochondrial oxoglutarate carrier studied by site directed spin-labeling. MOLECULAR MEMBRANE BIOLOGY, 25(3), 236-244.  
  • Chillemi, G., D’Annessa, I., Fiorani, P., Losasso, C., Benedetti, P., & Desideri, A. (2008). Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. NUCLEIC ACIDS RESEARCH, 36(17), 5645-5651.  
  • Falconi, M., Oteri, F., Eliseo, T., Cicero, D., & Desideri, A. (2008). MD simulations of papillomavirus DNA-E2 protein complexes hints at a protein structural code for DNA deformation. BIOPHYSICAL JOURNAL, 95, 1108-1117.
  •  Biancolella, M., Valentini, A., Minella, D., Vecchione, L., D’Amico, F., Chillemi, G., et al. (2007). Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. INVESTIGATIONAL NEW DRUGS, 25(5), 491-497.  
  • Amati, F., Biancolella, M., Farcomeni, A., Giallonardi, S., Bueno, S., Minella, D., et al. (2007). Dynamic changes in gene expression profiles of 22q11 and related orthologous genes during mouse development. GENE, 391(1-2), 91-102.
  • Cannata, S., Desideri, A., & Rufini, S. (2007). Anticorpo murino monoclonale diretto contro una tossina emolitica dell’attinia Stichodactyla helianthus.
  • Chillemi, G., Bruselles, A., Fiorani, P., Bueno, S., & Desideri, A. (2007). The open state of human topoisomerase I as probed by molecular dynamics simulation. NUCLEIC ACIDS RESEARCH, 35(9), 3032-3038.  
  • Falconi, M., Biocca, S., Novelli, G., & Desideri, A. (2007). Molecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant. BMC STRUCTURAL BIOLOGY, 7, 73-83.
  • Falconi, M., Santolamazza, A., Eliseo, T., De Prat- Gay, G., Cicero, D., & Desideri, A. (2007). Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation. THE FEBS JOURNAL, 274, 2385-2395.  
  • Valentini, A., Biancolella, M., Amati, F., Gravina, P., Miano, R., Chillemi, G., et al. (2007). Valproic acid induces neuroendocrine differentiation and UGT2B7 up-regulation in human prostate carcinoma cell line. DRUG METABOLISM AND DISPOSITION, 35(6), 968-972.
  • Gambardella, S., Biancolella, M., D’Apice, M., Amati, F., Sangiuolo, F., Farcomeni, A., et al. (2006). Gene expression profile study in CFTR mutated bronchial cell lines. CLINICAL AND EXPERIMENTAL MEDICINE, 6(4), 157-165.  
  • Falconi, M., Chillemi, G., Di Marino, D., D’Annessa, I., Morozzo della Rocca, B., Palmieri, L., et al. (2006). Structural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studies. PROTEINS, 65(3), 681-691.  
  • Bordo, D., Pesce, A., , B., Stroppolo, M.E., Falconi, M., & Desideri, A. (2006). Cu,Zn superoxide dismutase in prokaryotes and eukaryotes.. In K. Wieghardt, T. Poulos, & A. Messerschmidt (a cura di), Handbook of Metalloproteins (pp. 1284-1300). John Wiley & Sons, Ltd. London.  
  • Cicero, D., Falconi, M., Candi, E., Mele, S., Cadot, B., Di Venere, A., et al. (2006). NMR structure of the p63 SAM domain and dynamical properties of G534V and T537P pathological mutants, identified in the AEC syndrome. CELL BIOCHEMISTRY AND BIOPHYSICS, 44(3), 475-489.

Teaching

Teaching – link to Didattica web