Profile
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Giuseppe Sancesario sancesario@med.uniroma2.it Office/Location Department of Systems Medicine Tel: +39 06 72596002 Lab: +39 06 72596020 Fax: +39+0672596022 |
Biography
Biography
Born in Presicce (LE) Italy, on 17/08/1947
Graduated in Medicine in 1976 at the University of Rome “La Sapienza”, Italy;
Certified neurologist in 1980
Certified pathologist in 1992.
Post-doctoral fellow in the Department of Neuromorphology, Max-Planck-Institut fur psychiatry, Munich, Germany, from 1985 to 1986.
Tenured researcher in 1984.
Associate professor of Clinical Neurology at the Tor Vergata University of Rome in 1998.
Visiting professor in the Department of Anatomy and Neurobiology, the University of Tennessee, Memphis in 1993, 1995 e 1997.
Director of the School of Neurology, University of Rome – Tor Vergata in years 2004-2009.
Director of the “Centro Regionale Alzheimer” – Tor Vergata University Hospital in years 2006 – 2017.
President of the Italian Association of Neuropathology in years 2007-2009.
Since 1990 he is head of the Laboratory of Experimental Neuropathology in the Department of Systems Medicine at the Tor Vergata University of Rome.
Research
Research Activity
Dr. Sancesario is a neurologist with an expertise in experimental neuropathology. Dr. Sancesario’s studies have dealt with the mechanisms of ischemic brain damage and with the efficacy of various drugs in improving the vulnerability of neurons to ischemia, using different models of ischemia in rodents and evaluating morphologically the severity of the brain damage with light and electron microscope.
Another major field of interest of dr. Sancesario has regarded the neuropathology of basal ganglia in models of extrapyramidal disorders. He has studied the plasticity of striatal and pallidal neurons in manganese-treated or 6-OHDA-lesioned rodents. He and co-workers first identified a complex dys-regulation of the second messenger system in the basal ganglia after lesion of the substantia nigra. These results provide a better knowledge of the pathogenesis of parkinsonism and levodopa induced dyskinesia, opening the way to new therapeutic approaches.
His main clinical interest has been directed to diagnosis and treatment of Alzheimers’s disease and other dementia. In particular he oriented his research in studying the neuroanatomical correlates of the neurodegenerative processes using multimodal MRI and in searching CSF bio-markers of the disease processes. The specific scientific activity of dr. Sancesario is documented by 160 papers on international journals with referees.
Publications
Selected Publications
- Liguori C, Pierantozzi M, Chiaravalloti A, Sancesario GM, Mercuri NB, Franchini F, Schillaci O, Sancesario G. When Cognitive Decline and Depression Coexist in the Elderly: CSF Biomarkers Analysis Can Differentiate Alzheimer’s Disease from Late-Life Depression. Front Aging Neurosci. 2018 Feb 23;10:38.
- Liguori C, Chiaravalloti A, Nuccetelli M, Izzi F, Sancesario G, Cimini A, Bernardini S, Schillaci O, Mercuri NB, Fabio P. Hypothalamic dysfunction is related to sleep impairment and CSF biomarkers in Alzheimer’s disease. J Neurol. 2017 Nov;264(11):2215-2223.
- Schirinzi T, Di Lazzaro G, Sancesario GM, Colona VL, Scaricamazza E, Mercuri NB, Martorana A, Sancesario G. Levels of amyloid-beta-42 and CSF pressure are directly related in patients with Alzheimer’s disease. J Neural Transm (Vienna). 2017 Dec;124(12):1621-1625.
- Liguori C, Mercuri NB, Izzi F, Romigi A, Cordella A, Sancesario G, Placidi F. Obstructive Sleep Apnea is Associated With Early but Possibly Modifiable Alzheimer’s Disease Biomarkers Changes.Sleep. 2017 May 1;40(5).
- Liguori C, Chiaravalloti A, Sancesario G, Stefani A, Sancesario GM, Mercuri NB, Schillaci O, Pierantozzi M. Cerebrospinal fluid lactate levels and brain [18F]FDG PET hypometabolism within the default mode network in Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2016 Oct;43(11):2040-9. doi: 10.1007/s00259-016-3417-2.
- Chiaravalloti A, Koch G, Toniolo S, Belli L, Lorenzo FD, Gaudenzi S, Schillaci O, Bozzali M, Sancesario G, Martorana A. Comparison between Early-Onset and Late-Onset Alzheimer’s Disease Patients with Amnestic Presentation: CSF and (18)F-FDG PET Study.Dement Geriatr Cogn Dis Extra. 2016 Apr 5;6(1):108-19.
- Liguori C, Nuccetelli M, Izzi F, Sancesario G, Romigi A, Martorana A, Amoroso C, Bernardini S, Marciani MG, Mercuri NB, Placidi F. Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer’s disease. Neurobiol Aging. 2016 Apr;40:120-126.
- Spalletta G, Cravello L, Gianni W, Piras F, Iorio M, Cacciari C, Casini AR, Chiapponi C, Sancesario G, Fratangeli C, Orfei MD, Caltagirone C, Piras F. Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(3):807-16.
- Cesareo M, Martucci A, Ciuffoletti E, Mancino R, Cerulli A, Sorge RP, Martorana A, Sancesario G, Nucci C. Association Between Alzheimer’s Disease and Glaucoma: A Study Based on Heidelberg Retinal Tomography and Frequency Doubling Technology Perimetry. Front Neurosci. 2015 Dec 18;9:479.
- Martorana A, Di Lorenzo F, Belli L, Sancesario G, Toniolo S, Sallustio F, Sancesario GM, Koch G. Cerebrospinal Fluid Aβ42 Levels: When Physiological Become Pathological State. CNS Neurosci Ther. 2015 Nov 11.
- Spalletta G, Piras F, Piras F, Sancesario G, Iorio M, Fratangeli C, Cacciari C, Caltagirone C, Orfei MD. Neuroanatomical correlates of awareness of illness in patients with amnestic mild cognitive impairment who will or will not convert to Alzheimer’s disease.Cortex. 2014 Dec;61:183-95.
- Liguori C, Romigi A, Nuccetelli M, Zannino S, Sancesario G, Martorana A, Albanese M, Mercuri NB, Izzi F, Bernardini S, Nitti A, Sancesario GM, Sica F, Marciani MG, Placidi F. Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease. JAMA Neurol. 2014 Dec;71(12):1498-505.
- Liguori C, Stefani A, Sancesario G, Sancesario GM, Marciani MG, Pierantozzi M. CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):655-9.
- Liguori C, Romigi A, Mercuri NB, Nuccetelli M, Izzi F, Albanese M, Sancesario G, Martorana A, Sancesario GM, Bernardini S, Marciani MG, Placidi F. Cerebrospinal-fluid orexin levels and daytime somnolence in frontotemporal dementia. J Neurol. 2014 Sep;261(9):1832-6.
- Amadoro G, Corsetti V, Sancesario GM, Lubrano A, Melchiorri G, Bernardini S, Calissano P, Sancesario G. Cerebrospinal fluid levels of a 20-22 kDa NH2 fragment of human tau provide a novel neuronal injury biomarker in Alzheimer’s disease and other dementias. J Alzheimers Dis. 2014;42(1):211-26.
- Schirinzi T, Sancesario G, Anemona L, Pisani A, Sancesario G. CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone–a case report. Neurol Sci. 2014 Jul;35(7):1151-2.
- Spalletta G, Caltagirone C, Padovani A, Sorbi S, Attar M, Colombo D, Cravello L. Cognitive and affective changes in mild to moderate Alzheimer’s disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study. E V O L U T I O N study Working Group. PLoS One. 2014 Feb 19;9(2):e89216.
- Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Lachno DR, Lleó A, Lewczuk P, Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rosenmann H, Sancesario G, Schröder J, Shaw LM, Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K; Alzheimer’s Association QC Program Work Group. CSF biomarker variability in the Alzheimer’s Association quality control program. Alzheimers Dement. 2013 May;9(3):251-61.
- Sancesario G, Esposito Z, Mozzi AF, Sancesario GM, Martorana A, Giordano A, Sorge R, Mari B, Spalletta G, Marciani MG, Bernardini S. Transient global amnesia: linked to a systemic disorder of amino acid catabolism? J Neurol. 2013 May;260(5):1429-32.
- Esposito Z, Belli L, Toniolo S, Sancesario G, Bianconi C, Martorana A. Amyloid β, glutamate, excitotoxicity in Alzheimer’s disease: are we on the right track? CNS Neurosci Ther. 2013 Aug;19(8):549-55.
- Ferrazzoli D, Sancesario G.Development and significance of the frailty concept in the elderly: a possible modern view. CNS Neurol Disord Drug Targets. 2013 Jun;12(4):529-31. Review.
- Ferrazzoli D, Albanese M, Sica F, Romigi A, Sancesario G, Marciani MG, Mercuri NB, Izzi F, Placidi F.Electroencephalography and dementia: a literature review and future perspectives. CNS Neurol Disord Drug Targets. 2013 Jun;12(4):512-9.
- Koch G, Belli L, Giudice TL, Lorenzo FD, Sancesario GM, Sorge R, Bernardini S, Martorana A. Frailty among Alzheimer’s disease patients. CNS Neurol Disord Drug Targets. 2013 Jun;12(4):507-11. Review.
- – Sica F, Ferrazzoli D, Sancesario G. Sundowning syndrome: a possible marker of frailty in Alzheimer’s disease? CNS Neurol Disord Drug Targets. 2013 Jun;12(4):525-8. Review. PMID: 23574165
- Spalletta G, Gianni W, Giubilei F, Casini AR, Sancesario G, Caltagirone C, Cravello L. Rivastigmine patch ameliorates depression in mild AD: preliminary evidence from a 6-month open-label observational study. Alzheimer Dis Assoc Disord. 2013 Jul-Sep;27(3):289-91.
- Spalletta G, Cravello L, Piras F, Iorio M, Sancesario G, Marchi A, Caltagirone C, Cacciari C. Rapid-onset apathy may be the only clinical manifestation after dorsal striatum hemorrhagic lesion: a case report.Alzheimer Dis Assoc Disord. 2013 Apr-Jun;27(2):192-4. doi: 10.1097/WAD.0b013e318260ab97. PMID: 22760169
- Sancesario GM, Cencioni MT, Esposito Z, Borsellino G, Nuccetelli M, Martorana A, Battistini L, Sorge R, Spalletta G, Ferrazzoli D, Bernardi G, Bernardini S, Sancesario G. The load of amyloid-β oligomers is decreased in the cerebrospinal fluid of Alzheimer’s disease patients. J Alzheimers Dis. 2012;31(4):865-78.
- Martorana A, Sancesario GM, Esposito Z, Nuccetelli M, Sorge R, Formosa A, Dinallo V, Bernardi G, Bernardini S, Sancesario G. Plasmin system of Alzheimer’s disease patients: CSF analysis. J Neural Transm (Vienna). 2012 Jul;119(7):763-9.
- Martorana A, Esposito Z, Di Lorenzo F, Giacobbe V, Sancesario GM, Bucchi G, Bonnì S, Bernardini S, Sorge R, Sancesario G, Bernardi G, Caltagirone C, Koch G. Cerebrospinal fluid levels of Aβ42 relationship with cholinergic cortical activity in Alzheimer’s disease patients. J Neural Transm (Vienna). 2012 Jul;119(7):771-8.
- Amadoro G, Corsetti V, Stringaro A, Colone M, D’Aguanno S, Meli G, Ciotti M, Sancesario G, Cattaneo A, Bussani R, Mercanti D, Calissano P. A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration. J Alzheimers Dis. 2010;21(2):445-70.
- Di Paola M, Di Iulio F, Cherubini A, Blundo C, Casini AR, Sancesario G, Passafiume D, Caltagirone C, Spalletta G. When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study. Neurology. 2010 Apr 6;74(14):1136-42.
- Cherubini A, Péran P, Spoletini I, Di Paola M, Di Iulio F, Hagberg GE, Sancesario G, Gianni W, Bossù P, Caltagirone C, Sabatini U, Spalletta G. Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer’s disease patients. J Alzheimers Dis. 2010;19(4):1273-82.
- Angelucci F, Spalletta G, di Iulio F, Ciaramella A, Salani F, Colantoni L, Varsi AE, Gianni W,Sancesario G, Caltagirone C, Bossù P. Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels. Curr Alzheimer Res. 2010 Feb;7(1):15-20.
- Palmer K, Di Iulio F, Varsi AE, Gianni W, Sancesario G, Caltagirone C, Spalletta G. Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer’s disease: the role of depression and apathy. J Alzheimers Dis. 2010;20(1):175-83. doi: 10.3233/JAD-2010-1352.
- Cherubini A, Spoletini I, Péran P, Luccichenti G, Di Paola M, Sancesario G, Gianni W, Giubilei F, Bossù P, Sabatini U, Caltagirone C, Spalletta G. A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer’s disease patients. Neurosci Lett. 2010 Jan 22;469(2):214-8.
- Sancesario GM, Esposito Z, Nuccetelli M, Bernardini S, Sorge R, Martorana A, Federici G, Bernardi G, Sancesario G Abeta1-42 Detection in CSF of Alzheimer’s disease is influenced by temperature: indication of reversible Abeta1-42 aggregation? Exp Neurol. 2010 Jun;223(2):371-6. doi: 10.1016/j.expneurol.2009.07.028. Epub 2009 Aug 5.
- Stefani A, Sancesario G, Pierantozzi M, Leone G, Galati S, Hainsworth AH, Diomedi M. CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer’s and mixed dementia. J Neurol Sci. 2009 Aug 15;283(1-2):109-15. doi: 10.1016/j.jns.2009.02.343. Epub 2009 Mar 10. PMID: 19278690
- Martorana A, Mori F, Esposito Z, Kusayanagi H, Monteleone F, Codecà C, Sancesario G, Bernardi G, Koch G. Dopamine modulates cholinergic cortical excitability in Alzheimer’s disease patients. Neuropsychopharmacology. 2009 Sep;34(10):2323-8. doi: 10.1038/npp.2009.60. Epub 2009 Jun 10.PMID: 19516251
- Martorana A, Stefani A, Palmieri MG, Esposito Z, Bernardi G, Sancesario G, Pierantozzi M. L-dopa modulates motor cortex excitability in Alzheimer’s disease patients. J Neural Transm (Vienna). 2008 Sep;115(9):1313-9. doi: 10.1007/s00702-008-0082-z. Epub 2008 Jul 2.PMID: 18594753
- Spoletini I, Marra C, Di Iulio F, Gianni W, Sancesario G, Giubilei F, Trequattrini A, Bria P, Caltagirone C, Spalletta G. Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry. 2008 May;16(5):389-98. doi: 10.1097/JGP.0b013e318165dbce. Epub 2008 Apr 10.PMID: 18403572
- Alimonti A, Bocca B, Pino A, Ruggieri F, Forte G, Sancesario G. Elemental profile of cerebrospinal fluid in patients with Parkinson’s disease. J Trace Elem Med Biol. 2007;21(4):234-41. Epub 2007 Jul 3. PMID: 17980814
- Alimonti A, Ristori G, Giubilei F, Stazi MA, Pino A, Visconti A, Brescianini S, Sepe Monti M, Forte G, Stanzione P, Bocca B, Bomboi G, D’Ippolito C, Annibali V, Salvetti M, Sancesario G. Serum chemical elements and oxidative status in Alzheimer’s disease, Parkinson disease and multiple sclerosis. Neurotoxicology. 2007 May;28(3):450-6. Epub 2006 Dec 9. PMID: 17267042
- Bocca B, Alimonti A, Senofonte O, Pino A, Violante N, Petrucci F, Sancesario G, Forte G. Metal changes in CSF and peripheral compartments of parkinsonian patients. J Neurol Sci. 2006 Oct 25;248(1-2):23-30. Epub 2006 Jun 12.PMID: 16765382
- Forte G, Alimonti A, Violante N, Di Gregorio M, Senofonte O, Petrucci F, Sancesario G, Bocca B. Calcium, copper, iron, magnesium, silicon and zinc content of hair in Parkinson’s disease. J Trace Elem Med Biol. 2005;19(2-3):195-201. Epub 2005 Oct 24. PMID: 16325536
- Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B. Metals and oxidative stress in patients with Parkinson’s disease. Ann Ist Super Sanita. 2005;41(2):189-95. PMID: 16244392
- Forte G, Bocca B, Senofonte O, Petrucci F, Brusa L, Stanzione P, Zannino S, Violante N, Alimonti A, Sancesario G Trace and major elements in whole blood, serum, cerebrospinal fluid and urine of patients with Parkinson’s disease..J Neural Transm (Vienna). 2004 Aug;111(8):1031-40. Epub 2004 Mar 19.PMID: 15254791
- Tombini M, Koch G, Placidi F, Sancesario G, Marciani MG, Bernardi G. Temporal lobe epileptic activity mimicking dementia: a case report. Eur J Neurol. 2005 Oct;12(10):805-6. PMID: 16190919