Biography

Curriculum Vitae et Studiorum

Academic Position
Full Professor
Biochemistry
University of ROMA “Tor Vergata”
Department of CLINICAL SCIENCES AND TRANSLATIONAL MEDICINE

Academic Career
November 1996 – present Full Professor University of ROMA “Tor Vergata”
November 1990 – October 1996 Full Professor University of CAMERINO
April 1988 – October 1990 Associate Professor University of ROMA “La Sapienza”
June 1982 – March 1988 Research Scientist of CNR
November 1979 – July 1981 Fogarty Int. Fellow at Lab. Chem. Phys. NIH, USA

Scientific Responsabilities

•  1996-1999 Member of the Editorial Board of The Journal of Biological Inorganic Chemistry
• 2000-2006 Italian Representative in the Steering Committee of the European Project COST D21: “Metalloenzymes and Chemical Biomimetics”
• 2002-2008 Member of the Steering Committee of the Section “Chemistry of Biological Systems” of the Italian Chemical Society
• 2003-2005 National Coordinator of the PRIN Project 2003058409 “Structural and Functional Aspects of Metallopeptidases and Metalloproteinases and Their Role in Pathological Processes”
• 2011-present Deputy President of the Steering Committee of the Section “Chemistry of Biological Systems” of the Italian Chemical Society

Research Activity

Work in progress

Selected Publications

• Ascenzi P, Tundo GR, Coletta M. (2018) The nitrite reductase activity of ferrous human hemoglobin:haptoglobin 1-1 and 2-2 complexes. J. Inorg. Biochem. 187, 116-122.
• Mangiatordi GF, Guzzo T, Rossano EC, Trisciuzzi D, Alberga D, Fasciglione G,Coletta M, Topai A, Nicolotti O. (2018) Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors. Chem. Med. Chem. 13, 1343-1352.
• Malgieri G, D’Abrosca G, Pirone L, Toto A, Palmieri M, Russo L, Sciacca MFM, Tatè R, Sivo V, Baglivo I, Majewska R, Coletta M, Pedone PV, Isernia C, De Stefano M, Gianni S, Pedone EM, Milardi D, Fattorusso R. (2018) Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins. Chem Sci. 9, 3290-3298.
• Gioia M, Michaletti A, Scimeca M, Marini M, Tarantino U, Zolla L, Coletta M. (2018) Simulated microgravity induces a cellular regression of the mature phenotype inhuman primary osteoblasts. Cell Death Discov. 4, 59.
• Ascenzi P, De Simone G, Polticelli F, Gioia M, Coletta M. (2018) Reductive nitrosylation of ferric human hemoglobin bound to human haptoglobin 1-1 and 2-2. J. Biol. Inorg. Chem. 23, 437-445.
• Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-Dubouch MP, Marini S, Coletta M. (2018) The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S. Cell. Mol. Life Sci. 75, 3441-3456.
• Gioia M, Fasciglione GF, Sbardella D, Sciandra F, Casella M, Camerini S, Crescenzi M, Gori A, Tarantino U, Cozza P, Brancaccio A, Coletta M, Bozzi M. (2018) The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site. PLoS One13, e0192651.
• Paolino M, Brindisi M, Vallone A, Butini S, Campiani G, Nannicini C, Giuliani G, Anzini M, Lamponi S, Giorgi G, Sbardella D, Ferraris DM, Marini S, Coletta M, Palucci I, Minerva M, Delogu G, Pepponi I, Goletti D, Cappelli A, Gemma S, Brogi S. (2018) Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages. Chem. Med. Chem. 13, 422-430.
• Ascenzi P, Bocedi A, Gioia M, Fanali G, Fasano M, Coletta M. (2017) Warfarin inhibits allosterically the reductive nitrosylation of ferric human serum heme-albumin. J. Inorg. Biochem. 177, 63-75.
• Sinibaldi F, Milazzo L, Howes BD, Piro MC, Fiorucci L, Polticelli F, Ascenzi P, Coletta M, Smulevich G, Santucci R. (2017) The key role played by charge in the interaction of cytochrome c with cardiolipin. J. Biol. Inorg. Chem. 22, 19-29.
• Grasso G, Santoro AM, Lanza V, Sbardella D, Tundo GR, Ciaccio C, Marini S, Coletta M, Milardi D (2017). The double faced role of copper in Aβ homeostasis: a survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration. Coord. Chem. Rev. 347, 1-22.
• Ciaccio C, Tognaccini L, Battista T, Cervelli M, Howes BD, Santucci R, Coletta M, Mariottini P, Smulevich G, Fiorucci L. (2017) The Met80Ala and Tyr67His/Met80Ala mutants of human cytochrome c shed light on the reciprocal role of Met80 and Tyr67 in regulating ligand access into the heme pocket. J. Inorg. Biochem. 169, 86-96.
• Sbardella D, Tundo GR, Campagnolo L, Valacchi G, Orlandi A, Curatolo P, Borsellino G, D’Esposito M, Ciaccio C, Cesare SD, Di Pierro D, Galasso C, Santarone ME, Hayek J, Coletta M, Marini S. (2017) Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome. Sci. Rep. 7, 12297.
• Ascenzi P, Ciaccio C, De Simone G, Santucci R, Coletta M. (2017). Reductive nitrosylation of ferric carboxymethylated- cytochrome c. J. Porphyr. Phthaloc 21, 1-9.
• Ciaccio C, Di Pierro D, Sbardella D, Tundo GR, Curatolo P, Galasso C, Santarone ME, Casasco M, Cozza P, Cortelazzo A, Rossi M, De Felice C, Hayek J, Coletta M, Marini S. (2017) Oxygen exchange and energy metabolism in erythrocytes of Rett syndrome and their relationships with respiratory alterations. Mol. Cell. Biochem. 426, 205-213.
• Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M. (2017) Multiple functions of insulin-degrading enzyme: a metabolic crosslight? Crit. Rev. Biochem. Mol. Biol. 52, 554-582.
• Ascenzi P, Ciaccio C, Gasperi T, Pesce A, Caporaso L, Coletta M. (2017) Hydroxylamine-induced oxidation of ferrous carbonylated truncated hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni is limited by carbon monoxide dissociation. J. Biol. Inorg. Chem. 22, 977-986.
• Gioia M, Tomao L, Sbardella D, Ciaccio C, Tundo GR, di Masi A, Fasciglione GF, Marini S, Cozza P, Ascenzi P, Coletta M. (2017) Enzyme catalysis: the case of the prostate-specific antigen. Rend. Lincei Sci. Fis. Natur 28, S229-S237.
• Di Dato A, Cunsolo A, Persico M, Santoro AM, D’Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M. (2017) Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20s Conformation By Cooperative Binding. Sci. Rep. 7, 17098.
• Ascenzi P, Sbardella D, Sinibaldi F, Santucci R, Coletta M. (2016) The nitrite reductase activity of horse heart carboxymethylated-cytochrome c is modulated by cardiolipin. J. Biol. Inorg. Chem. 21, 421-432.
• Tognaccini L, Ciaccio C, D’Oria V, Cervelli M, Howes BD, Coletta M, Mariottini P, Smulevich G, Fiorucci L. (2016) Structure-function relationships in human cytochrome c: The role of tyrosine 67. J. Inorg. Biochem. 155, 56-66.
• Tundo GR, Di Muzio E, Ciaccio C, Sbardella D, Di Pierro D, Polticelli F, Coletta M, Marini S. (2016) Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin. FEBS J. 283, 3755-3770.
• Ascenzi P, Sbardella D, Santucci R, Coletta M. (2016) Cyanide binding to ferrous and ferric microperoxidase-11. J. Biol. Inorg. Chem. 21, 511-522.
• Santoro AM, Cunsolo A, D’Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R. (2016). Cationic porphyrins are tunable gatekeepers of the 20S proteasome. Chem. Science 7, 1286-1297.
• Tundo GR, Sbardella D, Ciaccio C, De Pascali S, Campanella V, Cozza P, Tarantino U, Coletta M, Fanizzi FP, Marini S. (2015) Effect of cisplatin on proteasome activity. J. Inorg. Biochem. 153, 253-258.
• Ascenzi P, Sbardella D, Fiocchetti M, Santucci R, Coletta M. (2015) NO2(-)-mediated nitrosylation of ferrous microperoxidase-11. J. Inorg. Biochem. 153, 121-127.
• Gioia M, Vindigni G, Testa B, Raniolo S, Fasciglione GF, Coletta M, Biocca S. (2015) Membrane cholesterol modulates LOX-1 shedding in endothelial cells. PLoS One 10, e0141270.
• Polticelli F, Zobnina V, Ciaccio C, de Sanctis G, Ascenzi P, Coletta M. (2015) Enhanced heme accessibility in horse heart mini-myoglobin. Insights from molecular modeling and reactivity studies. Arch. Biochem. Biophys. 585, 1-9.
• Sbardella D, Tundo GR, Sciandra F, Bozzi M, Gioia M, Ciaccio C, Tarantino U, Brancaccio A, Coletta M, Marini S. (2015) Proteasome activity is affected by fluctuations in Insulin-Degrading enzyme distribution. PLoS One 10, e0132455.
• Tilleman L, Abbruzzetti S, Ciaccio C, De Sanctis G, Nardini M, Pesce A, Desmet F, Moens L, Van Doorslaer S, Bruno S, Bolognesi M, Ascenzi P, Coletta M, Viappiani C, Dewilde S. (2015) Structural bases for the regulation of CO binding in the archaeal protoglobin from Methanosarcina acetivorans. PLoS One 10, e0125959.
• Ciaccio C, Ocaña-Calahorro F, Droghetti E, Tundo GR, Sanz-Luque E, Polticelli F, Visca P, Smulevich G, Ascenzi P, Coletta M. (2015) Functional and spectroscopic characterization of Chlamydomonas reinhardtii truncated hemoglobins. PLoS One 10, e0125005.
• Ascenzi P, Coletta M, Wilson MT, Fiorucci L, Marino M, Polticelli F, Sinibaldi F, Santucci R. (2015) Cardiolipin-cytochrome c complex: Switching cytochrome c from an electron-transfer shuttle to a myoglobin- and a peroxidase-like heme-protein. IUBMB Life. 67, 98-109.
• Ascenzi P, Leboffe L, di Masi A, Trezza V, Fanali G, Gioia M, Coletta M, Fasano M. (2015) Ligand Binding to the FA3-FA4 Cleft Inhibits the Esterase-Like Activity of Human Serum Albumin. PLoS One. 10, e0120603.
• di Masi A, Leboffe L, Trezza V, Fanali G, Coletta M, Fasano M, Ascenzi P. (2015) Drugs modulate allosterically heme-Fe-recognition by human serum albumin and heme-Fe-mediated reactivity. Curr Pharm Des. 21, 1837-1847.
• Ascenzi P, Leboffe L, Santucci R, Coletta M. (2015) Ferric microperoxidase-11 catalyzes peroxynitrite isomerization. J Inorg Biochem. 144, 56-61.
• Sbardella D, Sciandra F, Gioia M, Marini S, Gori A, Giardina B, Tarantino U, Coletta M, Brancaccio A, Bozzi M. (2015) α-dystroglycan is a potential target of matrix metalloproteinase MMP-2. Matrix Biol. 41, 2-7.
• Tundo GR, Sbardella D, De Pascali SA, Ciaccio C, Coletta M, Fanizzi FP, Marini S. (2015) Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells. J Biol Inorg Chem. 20, 101-108.
• Sbardella D, Tundo GR, Fasciglione GF, Gioia M, Bisicchia S, Gasbarra E, Ippolito E, Tarantino U, Coletta M, Marini S. (2014) Role of metalloproteinases in tendon pathophysiology. Mini Rev Med Chem. 14, 978-987.
• Tomao L, Sbardella D, Gioia M, Di Masi A, Marini S, Ascenzi P, Coletta M. (2014) Characterization of the prostate-specific antigen (PSA) catalytic mechanism: a pre-steady-state and steady-state study. PLoS One. 9, e102470.
• Ascenzi P, di Masi A, Tundo GR, Pesce A, Visca P, Coletta M. (2014) Nitrosylation mechanisms of Mycobacterium tuberculosis and Campylobacter jejuni truncated hemoglobins N, O, and P. PLoS One. 9, e102811.
• Ascenzi P, Marino M, Ciaccio C, Santucci R, Coletta M. (2014) Reductive nitrosylation of the cardiolipin-ferric cytochrome c complex. IUBMB Life 66, 438-447.
• Ascenzi P, Marino M, Polticelli F, Santucci R, Coletta M. (2014) Cardiolipin modulates allosterically the nitrite reductase activity of horse heart cytochrome c. J Biol Inorg Chem. 19, 1195-1201.
• Ascenzi P, Leboffe L, Pesce A, Ciaccio C, Sbardella D, Bolognesi M, Coletta M. (2014) Nitrite-reductase and peroxynitrite isomerization activities of Methanosarcina acetivorans protoglobin. PLoS One 9, e95391.
• Ascenzi P, Tundo GR, Fanali G, Coletta M, Fasano M. (2013) Warfarin modulates the nitrite reductase activity of ferrous human serum heme-albumin. J Biol Inorg Chem. Vol. 18, 939-946.
• Nucci C, Di Pierro D, Varesi C, Ciuffoletti E, Russo R, Gentile R, Cedrone C, Pinazo Duran MD, Coletta M, Mancino R. (2013) Increased malondialdehyde concentration and reduced total antioxidant capacity in aqueous humor and blood samples from patients with glaucoma. Mol Vis. Vol.19,1841-1846.
• Ascenzi P, Coletta A, Cao Y, Trezza V, Leboffe L, Fanali G, Fasano M, Pesce A, Ciaccio C, Marini S, Coletta M. (2013) Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N. PLoS One. Vol. 8, e69762.
• Pesce A, Tilleman L, Donné J, Aste E, Ascenzi P, Ciaccio C, Coletta M, Moens L, Viappiani C, Dewilde S, Bolognesi M, Nardini M. (2013) Structure and haem-distal site plasticity in Methanosarcina acetivorans protoglobin. PLoS One. Vol. 8, e66144.
• Sinibaldi F, Howes BD, Droghetti E, Polticelli F, Piro MC, Di Pierro D, Fiorucci L,Coletta M, Smulevich G, Santucci R. (2013) Role of lysines in cytochrome c-cardiolipin interaction. Biochemistry. Vol. 52, 4578-4588.
• Bocedi A, De Sanctis G, Ciaccio C, Tundo GR, Di Masi A, Fanali G, Nicoletti FP, Fasano M, Smulevich G, Ascenzi P, Coletta M. (2013) Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin. PLoS One. Vol. 8, e58842.
• Ciaccio C, Pesce A, Tundo GR, Tilleman L, Bertolacci L, Dewilde S, Moens L, Ascenzi P, Bolognesi M, Nardini M, Coletta M. (2013) Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin. Biochim Biophys Acta. Vol. 1834, 1813-1823.
• Ascenzi P, Marino M, Polticelli F, Coletta M, Gioia M, Marini S, Pesce A, Nardini M, Bolognesi M, Reeder BJ, Wilson MT. (2013) Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins. Biochim Biophys Acta. Vol. 1834, 1750-1756.
• Ascenzi P, Pesce A, Nardini M, Bolognesi M, Ciaccio C, Coletta M, Dewilde S. (2013) Reductive nitrosylation of Methanosarcina acetivorans protoglobin: a comparative study. Biochem Biophys Res Commun. Vol. 430, 1301-1305.
• Tundo GR, Sbardella D, Ciaccio C, Bianculli A, Orlandi A, Desimio MG, Arcuri G, Coletta M, Marini S. (2013) Insulin-degrading enzyme (IDE): a novel heat shock-like protein. J Biol Chem. Vol. 288, 2281-2289.
• Sbardella D, Inzitari R, Iavarone F, Gioia M, Marini S, Sciandra F, Castagnola M, Van den Steen PE, Opdenakker G, Giardina B, Brancaccio A, Coletta M, Bozzi M. (2012) Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse β-dystroglycan. IUBMB Life. Vol. 64, 988-994.
• Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C. (2012) ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus. Mol Biosyst. Vol. 8, 3295-3304.
• Petrera A, Amstutz B, Gioia M, Hähnlein J, Baici A, Selchow P, Ferraris DM, Rizzi M, Sbardella D, Marini S, Coletta M, Sander P. (2012) Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates. Biol Chem. Vol. 393, 631-640.
• Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E. (2012) Metal ions affect insulin-degrading enzyme activity. J Inorg Biochem. Vol. 117, 351-358.
• Ascenzi P, Gioia M, Fanali G, Coletta M, Fasano M. (2012) Pseudo-enzymatic hydrolysis of 4-nitrophenyl acetate by human serum albumin: pH-dependence of rates of individual steps. Biochem Biophys Res Commun. Vol. 424, 451-455.
• Tundo G, Ciaccio C, Sbardella D, Boraso M, Viviani B, Coletta M, Marini S. (2012). Somatostatin modulates insulin-degrading-enzyme metabolism: Implications for the regulation of microglia activity. PLoS One. Vol. 7, e34376.
• Abbruzzetti S, Tilleman L, Bruno S, Viappiani C, Desmet F, Van Doorslaer S, Coletta M, Ciaccio C, Ascenzi P, Nardini M, Bolognesi M, Moens L, Dewilde S. (2012). Ligation tunes protein reactivity in an ancient haemoglobin: Kinetic evidence for an allosteric mechanism in Methanosarcina acetivorans protoglobin.. PLoS One. vol. 7, e33614.
• Gullotta F, di Masi A, Coletta M, Ascenzi P. (2012). CO metabolism, sensing, and signaling. Biofactors. Vol. 38, 1-13.
• Fasciglione GF, Gioia M, Tsukada H, Liang J, Iundusi R, Tarantino U, Coletta M, Pourmotabbed T, Marini S. (2012). The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region.. JBIC. Vol. 17, 663-672
• Sbardella D, Fasciglione GF, Gioia M, Ciaccio C, Tundo GR, Marini S, Coletta M (2012). Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes. Mol Aspects Med. Vol. 33, 119-208.
• Cao Y, Nicoletti FP, De Sanctis G, Bocedi A, Ciaccio C, Gullotta F, Fanali G, Tundo GR, di Masi A, Fasano M, Smulevich G, Ascenzi P, Coletta M (2012). Evidence for pH-dependent multiple conformers in iron(II) heme-human serum albumin: spectroscopic and kinetic investigation of carbon monoxide binding. JBIC. Vol. 17, 133-147.
• Ascenzi P, Ciaccio C, Sinibaldi F, Santucci R, Coletta M (2011). Peroxynitrite detoxification by horse heart carboxymethylated cytochrome c is allosterically modulated by cardiolipin. Biochem Biophys Res Commun. Vol. 415, 463-467.
• Ascenzi P, Ciaccio C, Sinibaldi F, Santucci R, Coletta M (2011). Cardiolipin modulates allosterically peroxynitrite detoxification by horse heart cytochrome c. Biochem Biophys Res Commun. Vol. 404, 190-194.
• Howes BD, Giordano D, Boechi L, Russo R, Mucciacciaro S, Ciaccio C, Sinibaldi F, Fittipaldi M, Martì MA, Estrin DA, Di Prisco G, Coletta M, Verde C, Smulevich G (2011) The peculiar heme pocket of the 2/2 hemoglobin of cold-adapted Pseudoalteromonas haloplanktis TAC125. JBIC. Vol. 16, 299-311.
• Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E (2011). Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer’s disease. Chemistry-A European Journal. Vol. 17, 2752-2762.
• Ascenzi P, Gullotta F, Gioia M, Coletta M, Fasano M (2011). O(2)-mediated oxidation of ferrous nitrosylated human serum heme-albumin is limited by nitrogen monoxide dissociation. Biochem Biophys Res Commun. Vol. 406, 112-116.
• Ascenzi P, Polticelli F, Marino M, Santucci R, Coletta M (2011). Cardiolipin drives cytochrome c proapoptotic and antiapoptotic actions. IUBMB Life. Vol. 63, 160-165.
• Pesce A, Tilleman L, Dewilde S, Ascenzi P, Coletta M, Ciaccio C, Bruno S, Moens L, Bolognesi M, Nardini M (2011). Structural heterogeneity and ligand gating in ferric methanosarcina acetivorans protoglobin mutants. IUBMB Life. Vol. 63, 287-294.
• Mancino R, Di Pierro D, Varesi C, Cerulli A, Feraco A, Cedrone C, Pinazo-Duran MD, Coletta M, Nucci C (2011). Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy. Mol Vis. Vol. 17, 1298-1304.
• Giordano D, Russo R, Ciaccio C, Howes BD, Di Prisco G, Marden MC, Hui Bon Hoa G, Smulevich G, Coletta M, Verde C (2011). Ligand- and proton-linked conformational changes of the ferrous 2/2 hemoglobin of Pseudoalteromonas haloplanktis TAC125. IUBMB Life. Vol. 63, 566-573.
• Ascenzi P, Cao Y, Tundo GR, Coletta M, Fanali G., Fasano M (2011) Ibuprofen and warfarin modulate allosterically ferrous human serum heme-albumin nitrosylation. Biochem Biophys Res Commun. Vol. 411, 185-189.
• Ferraris DM, Sbardella D, Petrera A, Marini S, Amstutz B, Coletta M, Sander P, Rizzi M (2011). Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity. J Biol Chem. Vol. 286, 32475-32482.
• Ascenzi P, Bolli A, Di Masi A, Tundo GR, Fanali G, Coletta M, Fasano M (2011). Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme-albumin. JBIC. Vol. 16, 97-108.
• Sinibaldi F, Howes BD, Piro MC, Polticelli F, Bombelli C, Ferri T, Coletta M, Smulevich G, Santucci R (2010). Extended cardiolipin anchorage to cytochrome c: a model for protein-mitochondrial membrane binding. JBIC. Vol. 15, 689-700.
• Mazzuca C, Orioni B, Coletta M, Formaggio F, Toniolo C, Maulucci G, De Spirito M, Pispisa B, Venanzi M, Stella L (2010). Fluctuations and the rate-limiting step of peptide-induced membrane leakage. Biophys J. Vol. 99, 1791-1800.
• Ascenzi P, Santucci R, Coletta M, Polticelli F (2010). Cytochromes: Reactivity of the “dark side” of the heme. Biophys Chem. Vol. 152, 21-27.
• Ascenzi P, Cao Y, Di Masi A, Gullotta F, De Sanctis G, Fanali G, Fasano M, Coletta M (2010) Reductive nitrosylation of ferric human serum heme-albumin. FEBS J. Vol. 277, 2474-2485.
• Gioia M, Fasciglione GF, Monaco S, Iundusi R, Sbardella D, Marini S, Tarantino U, Coletta M (2010) pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain. JBIC. Vol. 15, 1219-1232.
• Ascenzi P, Di Masi A, Gullotta F, Mattu M, Ciaccio C, Coletta M (2010) Reductive nitrosylation of ferric cyanide horse heart myoglobin is limited by cyanide dissociation. Biochem Biophys Res Commun. Vol. 393, 196-200.
• De Marinis E, Casella L, Ciaccio C, Coletta M, Visca P, Ascenzi P (2009) Catalytic peroxidation of nitrogen monoxide and peroxynitrite by globins. IUBMB Life. Vol. 61, 62-73.
• Ascenzi P, Di Masi A, Coletta M, Ciaccio C, Fanali G, Nicoletta FP, Smulevich G, Fasano M (2009) Ibuprofen impairs allosterically peroxynitrite isomerization by ferric human serum heme-albumin. J Biol Chem. Vol. 284, 31006-31017.
• Gemma S, Campiani G, Butini S, Joshi BP, Kukreja G, Coccone SS, Bernetti M, Persico M, Nacci V, Fiorini I, Novellino E, Taramelli D, Basilico N, Parapini S, Yardley V, Croft S, Keller-Maerki S, Rottmann M, Brun R, Coletta M, Marini S, Guiso G, Caccia S, Fattorusso C (2009). Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. J Med Chem. Vol. 52, 502-513.
• Gioia M, Monaco S, Van den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M (2009) The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B. J Mol Biol. Vol. 386, 419-434.
• Pesce A, Thijs L, Nardini M, Desmet F, Sisinni L, Gourlay L, Bolli A, Coletta M, Van Doorslaer S, Wan X, Alam M, Ascenzi P, Moens L, Bolognesi M, Dewilde S (2009) HisE11 and HisF8 provide bis-histidyl heme hexa-coordination in the globin domain of Geobacter sulfurreducens globin-coupled sensor. J Mol Biol. Vol. 386, 246-260.
• Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M (2009) Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity. J Mol Biol. Vol. 385, 1556-1567.
• Ascenzi P, De Marinis E, Di Masi A, Ciaccio C, Coletta M (2009) Peroxynitrite scavenging by ferryl sperm whale myoglobin and human hemoglobin. Biochem Biophys Res Commun. Vol. 390, 27-31.
• Ascenzi P, Di Masi A, De Sanctis G, Coletta M, Fasano M (2009) Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites. Biochem Biophys res Commun. Vol. 387, 83-86.
• Ascenzi P, De Marinis E, Visca P, Ciaccio C, Coletta M (2009). Peroxynitrite detoxification by ferryl Mycobacterium leprae truncated hemoglobin O. Biochem Biophys Res Commun. Vol. 380, 392-396.
• Bozzi M, Inzitari R, Sbardella D, Monaco S, Pavoni E, Gioia M, Marini S, Morlacchi S, Sciandra F, Castagnola M, Giardina B, Brancaccio A, Coletta M (2009) Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site. IUBMB Life. Vol. 61, 1143-1152.
• Fanali G, De Sanctis G, Gioia M, Coletta M, Ascenzi P, Fasano M (2009). Reversible two-step unfolding of heme-human serum albumin: a (1)H-NMR relaxometric and circular dichroism study. JBIC. Vol. 14, 209-217.
• Lauceri R, Fasciglione GF, D’Urso A, Marini S, Purrello R, Coletta M (2008) Kinetic investigation of porphyrin interaction with chiral templates reveals unexpected features of the induction and self-propagation mechanism of chiral memory. J Am Chem Soc. Vol. 130, 10476-10477.
• Ciaccio C, Coletta A, De Sanctis G, Marini S, Coletta M (2008). Cooperativity and allostery in haemoglobin function. IUBMB Life. Vol. 60, 112-123.
• Aureli L, Gioia M, Cerbara I, Monaco S, Fasciglione GF, Marini S, Ascenzi P, Topai A, Coletta M (2008) Structural bases for substrate and inhibitor recognition by matrix metalloproteinases. Curr Med Chem. Vol. 15, 2192-2222.
• Lombardi F, Fasciglione GF, D’Apice MR, Vielle A, D’Adamo M, Sbraccia P, Marini S, Borgiani P, Coletta M, Novelli G (2008). Increased release and activity of matrix metalloproteinase-9 in patients with mandibuloacral dysplasia type A, a rare premature ageing syndrome. Clin Gen. Vol. 74, 374-383.
• Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R (2008) Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength. Biochemistry. Vol. 47, 6928-6935.
• Ascenzi P, De Marinis E, Coletta M, Visca P (2008) H2O2 and NO scavenging by Mycobacterium leprae truncated hemoglobin O. Biochem Biophys Res Commun. Vol. 373, 197-201.
• Gemma S, Campiani G, Butini S, Kukreja G, Coccone SS, Joshi, BP, Persico M, Nacci V, Fiorini I, Novellino E, Fattorusso E, Taglialatela-Sscafati O, Savini L, Taramelli D, Basilico N, Parapini S, Morace G, Yardley VF, Croft S, Coletta M, Marini S, Fattorusso C (2008) Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. J Med Chem. Vol. 51, 1278-1294.
• Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M (2008) Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity. EMBO Rep. Vol. 9, 157-163.
• Bolli A, Ciaccio C, Coletta M, Nardini M, Bolognesi M, Pesce A, Guertin M, Visca P, Ascenzi P (2008) Ferrous Campylobacter jejuni truncated hemoglobin P displays an extremely high reactivity for cyanide – a comparative study. FEBS J. Vol. 275, 633-645.
• Ascenzi P, Imperi F, Coletta M, Fasano M (2008). Abacavir and warfarin modulate allosterically kinetics of NO dissociation from ferrous nitrosylated human serum heme-albumin. Biochem Biophys Res Commun. Vol. 369, 686-691.
• Smulevich G, Droghetti E, Focardi C, Coletta M, Ciaccio C, Nocentini M (2007). A rapid spectroscopic method to detect the fraudulent treatment of tuna fish with carbon monoxide. Food Chem. Vol. 101, 1071-1077.
• Ascenzi P, Bellelli A, Coletta M, Colosimo A, Falcioni G, Giacometti GM, Ippoliti R, Zolla L, Giardina B (2007) Multiple strategies for O2 transport: from simplicity to complexity. IUBMB Life. Vol. 59, 1-17.
• Gioia M, Monaco S, Fasciglione GF, Coletti A, Modesti A, Marini S, Coletta M (2007) Characterization of the mechanisms by which Gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains. J Mol Biol. Vol. 368, 1101-1113.
• Saladino R, Fiani C, Crestini C, Argyropoulos DS, Marini S, Coletta M (2007). An efficient and stereoselective dearylation of asarinin and sesamin tetrahydrofluorofuran lignans to acuminatolide by methyltrioxorhenium/H2O2 and UHP systems. J Nat Prod. Vol. 70, 39-42.
• Thijs L, Vinck E, Bolli A, Trandafir F, Wan X, Hoogewijs D, Coletta M, Fago A, Weber RE, Van Doorslaer S, Ascenzi P, Alam M, Moens L, Dewilde S (2007) Characterization of a globin-coupled oxygen sensor with a gene-regulating function. J Biol Chem. Vol. 282, 37325-37340.
• Ascenzi P, Petrella G, Coletta M (2007) Ferricyanide-mediated oxidation of ferrous nitrosylated sperm whale myoglobin involves the formation of the ferric nitrosylated intermediate. Biochem Biophys Res Commun. Vol. 359, 871-876.
• Feis A, Tofani L, De Sanctis G, Coletta M, Smulevich G (2007) Multiphasic kinetics of myoglobin/SDS complex formation. Biophys J. Vol. 92, 4078-4087.
• De Sanctis G, Petrella G, Ciaccio C, Feis A, Smulevich G, Coletta M (2007) A comparative study on axial coordination and ligand binding in ferric mini myoglobin and horse heart myoglobin. Biophys J. Vol. 93, 2135-2142.
• Ascenzi P, Ciaccio C, Coletta M (2007) Peroxynitrite-mediated oxidation of ferrous carbonylated myoglobin is limited by carbon monoxide dissociation. Biochem Biophys Res Commun. Vol. 363, 931-936.
• Monaco S, Gioia M, Rodriguez J, Fasciglione GF, Di Pierro D, Lupidi G, Krippahl L, Marini S, Coletta M (2007). Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen. Biochem J. Vol. 402, 503-513.
• Casalinuovo IA, Di Pierro D, Bruno E, Di Francesco P, Coletta M (2006). Experimental use of a new surface acoustic wave sensor for the rapid identification of bacteria and yeasts. Lett. Appl Microbiol. Vol. 42, 24-29.
• Rodriguez J, Di Pierro D, Gioia M, Monaco S, Delgado R, Coletta M, Marini S (2006) Effects of a natural extract from Mangifera indica L, and its active compound, mangiferin, on energy state and lipid peroxidation of red blood cells. Biochim Biophys Acta. Vol. 1760, 1333-1342.
• Ciaccio C, Gambacurta A, De Sanctis G, Spagnolo D, Sakarikou C, Petrella G, Coletta M (2006) rhEPO (recombinant human eosinophil peroxidase): expression in Pichia pastoris and biochemical characterization. Biochem J. Vol. 395, 295-301.
• Monaco S, Sparano V, Gioia M, Sbardella D, Di Pierro D, Marini S, Coletta M (2006) Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains. Prot Sci. Vol. 15, 2805-2815.
• Sinibaldi F, Piro MC, Coletta M, Santucci R (2006) Salt-induced formation of the A-state of ferricytochrome c–effect of the anion charge on protein structure. FEBS J. Vol. 273, 5347-5357.
• De Sanctis G, Fasciglione GF, Marini S, Sinibaldi F, Santucci R, Monzani E, Dallacosta C, Casella L, Coletta M (2006) pH-dependent redox and CO binding properties of chelated protoheme-L-histidine and protoheme-glycyl-L-histidine complexes.. JBIC. Vol. 11, 153-167.
• Fattorusso C, Gemma S, Butini S, Huleatt P, Catalanotti B, Persico M, De Angelis M, Fiorini I, Nacci V, Ramunno A, Rodriquez M, Greco G, Novellino E, Bergamini A, Marini S, Coletta M, Maga G, Spadari S, Campiani G. (2005). Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. J Med Chem. Vol. 48, 7153-7165.
• Ascenzi P, Bocedi A, Fasano M, Gioia M, Marini S, Coletta M (2005). Proton-linked subunit heterogeneity in ferrous nitrosylated human adult hemoglobin: an EPR study. J Inorg. Biochem. Vol. 99, 1255-1259.
• Clementi ME, Marini S, Coletta M, Orsini F, Giardina B (2005) Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35. FEBS Lett. Vol. 579, 2913-2918.
• Misiti F., Sampaolese B, Pezzotti M, Marini S, Coletta M, Ceccarelli L, Giardina B, Clementi ME (2005) Abeta(31-35) peptide induce apoptosis in PC 12 cells: contrast with Abeta(25-35) peptide and examination of underlying mechanisms. Neurochem Int. Vol. 46, 575-583.
• Fasano M, Bocedi A, Mattu M, Coletta M, Ascenzi P (2004) Nitrosylation of rabbit ferrous heme-hemopexin. JBIC. Vol. 9, 800-806.
• Ciaccio C, De Sanctis G, Marini S, Sinibaldi F, Santucci R, Arcovito A, Bellelli A, Ghibaudi E, Ferrari RP, Coletta M (2004) Proton linkage for CO binding and redox properties of bovine lactoperoxidase. Biophys J. Vol. 86, 448-454.
• De Sanctis G, Ciaccio C, Fasciglione GF, Fiorucci L, Gioia M, Sinibaldi F, Marini S, Santucci R, Coletta M (2004) Effect of axial coordination on the kinetics of assembly and folding of the two halves of horse heart cytochrome c. J Biol Chem. Vol. 279, 52860-52868.
• Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V (2003) Design of a new mimochrome with unique topology.. Chemistry. Vol. 9, 5643-5654.
• Sinibaldi F, Howes BD, Smulevich G, Ciaccio C, Coletta M, Santucci R (2003) Anion concentration modulates the conformation and stability of the molten globule of cytochrome c. JBIC. Vol. 8, 663-670.
• Ascenzi P, Bocedi A, Bolognesi M, Spallarossa A, Coletta M, De Cristofaro R, Menegatti E, Coletta M (2003) The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein. Curr Prot Pept Sci. Vol. 4, 231-251.
• Marini S, Fasciglione GF, Monteleone G, Maiotti M, Tarantino U, Coletta M (2003) A correlation between knee cartilage degradation observed by arthroscopy and synovial proteinase activities. Clin Biochem. Vol. 36, 295-304.
• Ciaccio C, Rosati A, De Sanctis G, Sinibaldi F, Marini S, Santucci R, Ascenzi P, Welinder KG, Coletta M (2003) Relationships of ligand binding, redox properties and protonation in Coprinus cinereus peroxidase. J Biol Chem. Vol. 278, 18730-18737.
• Petruzzelli R, Clementi ME, Marini S, Coletta M, Di Stasio E, Giardina B, Misiti F (2003) Respiratory inhibition of isolated mammalian mitochondria by salivary antifungal peptide histatin-5. Biochem Biophys Res Commun. Vol. 311, 1034-1040.
• Mugnaini C, Botta M, Coletta M, Corelli F, Focher F, Marini S, Renzulli ML, Verri A (2003) Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2′,3′- dideoxy-3′-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides. Bioorg Med Chem. Vol. 11, 357-366.
• Micheli L, Di Stefano S, Moscone D, Palleschi G, Marini S, Coletta M, Draisci R, Delli Quadri F (2002) Production of antibodies and development of highly sensitive formats of enzyme immunoassay for saxitoxin analysis.. Anal Bioanal Chem. Vol. 373, 678-684.
• Feis A, Santoni E, Neri F, Ciaccio C, De Sanctis G, Coletta M, Welinder KG, Smulevich G (2002) Fine-tuning of the binding and dissociation of CO by the amino acids of the heme pocket of Coprinus cinereus peroxidase. Biochemistry. Vol. 41, 13264-13273.
• Visca P, Fabozzi G, Petrucca A, Ciaccio C, Coletta M, De Sanctis G, Bolognesi M, Milani M, Ascenzi P. (2002) The truncated hemoglobin from Mycobacterium leprae. Biochem Biophys Res Commun. Vol. 294, 1064-1070.
• Gioia M, Fasciglione GF, Marini S, D’Alessio S., De Sanctis G, Diekmann O, Pieper M, Politi V, Tschesche H, Coletta M (2002) Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain. J Biol Chem. Vol. 277, 23123-23130.
• Fasano M, Mattu M, Coletta M, Ascenzi P (2002) The heme-iron geometry of ferrous nitrosylated heme-serum lipoproteins, hemopexin, and albumin: a comparative EPR study. J Inorg Biochem. Vol. 91, 487-490.
• Campiani G, Aiello F, Fabbrini M, Morelli E, Ramunno A, Armaroli S, Nacci V, Garofalo A, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Ventura L, Bongiovanni B, Capozzi M, Bolacchi F, Marini S, Coletta M, Guiso G, Caccia S (2001) Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.. J Med Chem. Vol. 44, 305-315.
• Angeletti M, Pucciarelli S, Priori AM, Canofeni S, Barra D, Fioretti E, Coletta M (2001) Different functional modulation by heterotropic ligands (2,3-diphosphoglycerate and chlorides) of the two haemoglobins from fallow-deer Dama dama. Eur J Biochem. Vol. 268, 603-611.
• Mattu M, Vannini A, Coletta M, Fasano M, Ascenzi P. (2001). Effect of bezafibrate and clofibrate on the heme-iron geometry of ferrous nitrosylated heme-human serum albumin: an EPR study. J Inorg Biochem. Vol. 84, 293-296.
• Pallini M, Compagnone D, Di Stefano S, Marini S, Coletta M, Palleschi G (2001) Immunodetection of lactosylated proteins as a useful tool to determine heat treatment in milk samples. Analyst. Vol.126, 66-70.
• Maiotti M, Monteleone G, Tarantino U, Fasciglione GF, Marini S, Coletta M (2000) Correlation between osteoarthritic cartilage damage and levels of proteinases and proteinase inhibitors in synovial fluid from the knee joint. Arthroscopy. Vol. 16, 522-526.
• Campiani G, Fabbrini M, Morelli E, Nacci V, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Fracasso C, Caccia S (2000) Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents. Antivir Chem Chemother. Vol. 11, 141-155.
• Fasciglione GF, Marini S, D’Alessio S, Politi V, Coletta M (2000) pH- and temperature-dependence of functional modulation in metalloproteinases: a comparison between neutrophil collagenase and Gelatinases A and B. Biophys J. Vol. 79, 2138-2149.
• Santucci R, Bongiovanni C, Marini S, Del Conte R, Tien M, Banci L, Coletta M (2000) Redox equilibria of manganese peroxidase from Phanerochaetes chrysosporium: functional role of residues on the proximal side of the haem pocket. Biochem J. Vol. 349, 85-90.
• Priori AM, Indiani C, De Sanctis G, Marini S, Santucci R, Smulevich G, Coletta M (2000) Anion- and pH-linked conformational transition in horseradish peroxidase. J Inorg Biochem. Vol. 79, 25-30.
• Erba F, Fiorucci L, Sommerhoff CP, Coletta M, Ascoli F (2000). Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin. Biol Chem. Vol. 381, 1117-1122.
• Marini S, Fasciglione GF, De Sanctis G, D’Alessio S, Politi V, Coletta M (2000) Cleavage of bovine collagen I by neutrophil collagenase MMP-8. Effect of pH on the catalytic properties as compared to synthetic substrates. J Biol Chem. Vol. 275, 18657-18663.
• Indiani C, De Sanctis G, Neri F, Santos H, Smulevich G, Coletta M (2000) Effect of pH on axial ligand coordination of cytochrome c” from Methylophilus methylotrophus and horse heart cytochrome c. Biochemistry. Vol. 39, 8234-8242.
• Campiani G, Morelli E, Fabbrini M, Nacci V, Greco G, Novellino E, Ramunno A, Maga G, Spadari S, Caliendo G, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Nacca A, Caccia S (1999) Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. J Med Chem. Vol. 42, 4462-4470.
• Lupidi G, Angeletti M, Eleuteri AM, Tacconi R, Coletta M, Fioretti E (1999) Peroxynitrite-mediated oxidation of fibrinogen inhibits clot formation. FEBS Lett. Vol. 462, 236-240.
• Coletta M, Angeletti M, Ascenzi P, Bertollini A, Della Longa S, De Sanctis G, Priori AM, Santucci R, Amiconi G (1999) Coupling of the oxygen-linked interaction energy for inositolhexakisphosphate and bezafibrate binding to human HbA0. J Biol Chem. Vol. 274, 6865-6874.
• Coletta M, Angeletti M, Ascone I, Boumis G, Castellano AC, Dell’Ariccia M, Della Longa S, De Sanctis G, Priori AM, Santucci R, Feis A, Amiconi G (1999). Heterotropic effectors exert more significant strain on monoligated than on unligated hemoglobin. Biophys J. Vol. 76, 1532-1536.
• Bolognesi M, Boffi A, Coletta M, Mozzarelli A, Pesce A, Tarricone C, Ascenzi P (1999) Anticooperative ligand binding properties of recombinant ferric Vitreoscilla homodimeric hemoglobin: a thermodynamic, kinetic and X-ray crystallographic study. J Mol Biol. Vol. 291, 637-650.
• Tamburrini M, Romano M, Carratore V, Kunzmann A, Coletta M, Di Prisco G (1998) The hemoglobins of the antarctic fishes Atedidraco orianae and Pogonophryne scotti. Amino acid sequence, lack of cooperativity, and ligand binding properties. J Biol Chem. Vol. 273, 32452-32459.
• Polizio F, De Sanctis G, Ascenzi P, Coletta M (1998) Anion and pH-linked effects on the heme-iron geometry in ferrous nitrosylated monomeric myoglobins. JBIC. Vol. 3, 458-462.
• Erba F, Fiorucci L, Coletta M, Ascoli F (1998) Bovine mast cell tryptase inactivation: effect of temperature. Peptides. Vol. 19, 437-443.
• Aime S, Fasano M, Paoletti S, Bellelli A, Coletta M, Ascenzi P (1998) Stabilization of the T-state of ferrous human adult and fetal hemoglobin by Ln(III) complexes: a thermodynamic study. J Inorg Biochem. Vol. 71, 37-43.
• Coletta M, Ascenzi P, Polizio F, Smulevich G, del Gaudio R, Piscopo M, Geraci G (1998) Cooperative mechanism in the homodimeric myoglobin from Nassa mutabilis. Biochemistry. Vol. 37, 2873-2878.
• Messana I, Angeletti M, Castagnola M, De Sanctis G, Di Stasio E, Giardina B, Pucciarelli S, Coletta M (1998). Thermodynamics of inositol hexakisphosphate interaction with human oxyhemoglobin. J Biol Chem. Vol. 273, 15329-15334.
• Coletta M, Costa H, De Sanctis G, Neri F, Smulevich G, Turner DL, Santos H (1997) pH dependence of structural and functional properties of oxidized cytochrome c” from Methylophilus methylotrophus. J Biol Chem. Vol. 272, 24800-24804.
• Fiorucci L, Erba F, Bolognesi M, Coletta M, Ascoli F (1997) pH dependence of bovine mast cell tryptase catalytic activity and of its inhibition by 4′,6-diamidino-2-phenylindole.. FEBS Lett. Vol. 408, 85-88.
• Angeletti M, Lupidi G, Eleuteri AM, Tacconi R, Coletta M (1997) Effect of aluminum on the binding properties of alpha-chymotrypsin. JBIC. Vol. 2, 320-326,
• Smulevich G, Paoli M, De Sanctis G, Mantini AR, Ascoli F, Coletta M (1997) Spectroscopic evidence for a conformational transitino in horseradish peroxidase at very low pH. Biochemistry. Vol. 36, 640-649.
• Coletta M, Ascenzi P, D’Avino R, Di Prisco G (1996) Proton-linked subunit kinetic heterogeneity for carbon monoxide binding to hemoglobin from Chelidonichthys kumu. J Biol Chem. Vol. 271, 29859-29864.
• Coletta M, Angeletti M, De Sanctis G, Cerroni L, Giardina B, Amiconi G, Ascenzi P (1996) Kinetic evidence for the existence of a rate-limiting step in the reaction of ferric hemoproteins with anionic ligands.. Eur J Biochem. Vol. 235, 49-53.
• Viola F, Aime S, Coletta M, Desideri A, Fasano M, Paoletti S, Tarricone C, Ascenzi P (1996) Azide, cyanide, fluoride, imidazole and pyridine binding to ferric and ferrous native horse heart cytochrome c and to its carboxymethylated derivative: a comparative study. J Inorg Biochem. Vol. 62, 213-222.
• Balliano G, Milla P, Giordano C, Gallina C, Coletta M, Menegatti E, Rizzi M, Bolognesi M, Ascenzi P (1996) N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p-nitrophenyl ester: a novel, high selective and optimal chromogenic active site titrant for human and bovine alpha-, beta- and gamma-thrombin. Biochem Biophys Res Commun. Vol. 225, 557-561.
• Giardina B, Ascenzi P, Clementi ME, De Sanctis G, Rizzi M, Coletta M (1996) Functional modulation by lactate of myoglobin. A monomeric allosteric hemoprotein. J Biol Chem. Vol. 271, 16999-17001.
• Coletta M, Ascenzi P, Castagnola M, Giardina B (1995) Functional and spectroscopic evidence for a conformational transition in ferrous liganded human hemoglobin. J Mol Biol. Vol. 249, 800-803.
• Smulevich G, Mantini AR, Paoli M, Coletta M, Geraci G (1995) Resonance Raman studies of the heme active site of the homodimeric myoglobin from Nassa mutabilis: a peculiar case.. Biochemistry. Vol. 34, 7507-7516.
• Fiorucci L, Erba F, Coletta M, Ascoli F (1995) Evidence for multiple interacting binding sites in bovine tryptase. FEBS Lett. Vol. 363, 81-84.
• Duprat AF, Traylor TG, Wu GZ, Coletta M, Sharma VS, Walda KN, Magde D (1995) Myoglobin-NO at low pH: free four-coordinated heme in the protein pocket.. Biochemistry. Vol. 34, 2634-2644.
• Nardini M, Tarricone C, Rizzi M, Lania A, Desideri A, De Sanctis G, Coletta M, Petruzzelli R, Ascenzi P, Coda A, et al. (1995) Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 Ǻ resolution. J Mol Biol. Vol. 247, 459-465.
• Ascenzi P, Amiconi G, Bode W, Bolognesi M, Coletta M, Menegatti E (1995) Proteinase inhibitors from the european medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects. Mol Aspects Med. Vol. 16, 215-313.
• Gambacurta A, Piro MC, Coletta M, Clementi ME, Polizio F, Desideri A, Santucci R, Ascoli F (1995) A single mutation (Thr72–>Ile) at the subunit interface is crucial for the functional properties of the homodimeric co-operative haemoglobin from Scapharca inaequivalvis. J Mol Biol. Vol. 248, 910-917.
• Fioretti E, Angeletti M, Lupidi G, Coletta M (1994) Heterotropic modulation of the protease-inhibitor-recognition process. Cations effect the binding properties of alpha-chymotrypsin. Eur J Biochem. Vol. 225, 459-465.
• Ascenzi P, Coletta M, Santucci R, Polizio F, Desideri A (1994) Nitric oxide binding to ferrous native horse heart cytochrome c and to its carboxymethylated derivative: a spectroscopic and thermodynamic study. J Inorg Biochem. Vol. 53, 273-280.
• Coletta M, Condo SG, Scatena R, Clementi ME, Baroni S, Sletten SN, Brix O, Giardina B (1994) Synergistic modulation by chloride and organic phosphates of hemoglobin from bear (Ursus arctos). J Mol Biol. Vol. 236, 1401-1406.
• Fago A, Romano M, Tamburrini M, Coletta M, D’Avino R, Di Prisco G (1993) A polymerising Root-effect fish hemoglobin with high subunit heterogeneity. Correlation with primary structure. Eur J Biochem. Vol. 218, 829-835.
• Petruzzelli R, Aureli G, Casale E, Nardini M, Rizzi M, Ascenzi P, Coletta M, De Sanctis G, Desideri A, Galtieri A, et al. (1993) Structural studies on the loggerhead sea turtle (Caretta caretta) myoglobin. Biochem Mol Biol Int. Vol. 31, 19-24.
• Coletta M, Ascenzi P, Santucci R, Bertollini A, Amiconi G (1993) Interaction of inositolhexakisphosphate with liganded ferrous human hemoglobin. Direct evidence for two functionally operative binding sites. Biochim Biophys Acta. Vol. 1162, 309-314.
• Fioretti E, Angeletti M, Coletta M, Ascenzi P, Bolognesi M, Menegatti E, Rizzi M, Ascoli F (1993) Binding of bovine basic pancreatic trypsin inhibitor (Kunitz) as well as bovine and porcine pancreatic secretory trypsin inhibitor (Kazal) to human cathepsin G: a kinetic and thermodynamic study. J Enz Inhib. Vol. 7, 57-64.
• Ascenzi P, Bertollini A, Coletta M, Desideri A, Giardina B, Polizio F, Santucci R, Scatena R, Amiconi G (1993) Cooperative effect of inositol hexakisphosphate, bezafibrate, and clofibric acid on the spectroscopic properties of the nitric oxide derivative of ferrous human hemoglobin. J Inorg Biochem. Vol. 50, 263-272.
• Ascenzi P, Clementi ME, Condò SG, Coletta M, Petruzzelli R, Polizio F, Rizzi M, Giunta C, Peracino V, Giardina B (1993) Functional, spectroscopic and structural properties of haemoglobin from chamois (Rupicapra rupicapra) and steinbock (Capra hircus ibex). Biochem J. Vol. 296, 361-365.
• Colotti G, Boffi A, Verzili D, Coletta M, Chiancone E (1992) The homodimeric hemoglobin from Scapharca can be locked into new cooperative structures upon reaction of Cys92, located at the subunit interface, with organomercurials.. FEBS Lett. Vol. 314, 481-485.
• Ascenzi P, Coletta M, Desideri A, Polizio F, Bertollini A, Santucci R, Amiconi G (1992) Effect of bezafibrate and clofibric acid on the spectroscopic properties of the nitric oxide derivative of ferrous human hemoglobin. J Inorg Biochem. Vol. 48, 47-53.
• Conti E, Casale E, Ascenzi P, Coletta M, Condo SG, Merli A, Giardina B, Bordo D, Bolognesi M (1992) Structural study and preliminary crystallographic data for the hemoglobin from reindeer (Rangifer tarandus tarandus). Biochem Biophys Res Commun. Vol. 187, 1063-1070.
• Coletta M, Clementi ME, Ascenzi P, Petruzzelli R, Condò SG, Giardina B (1992) A comparative study of the temperature dependence of the oxygen-binding properties of mammalian hemoglobins. Eur J Biochem. Vol. 204, 1155-1157.
• Coletta M, Ascenzi P, Smulevich G, Mantini AR, Del Gaudio R, Piscopo M, Geraci G (1992) Alteration of the proximal bond energy in the unliganded form of the homodimeric myoglobin from Nassa mutabilis. Kinetic and spectroscopic evidence. FEBS Lett. Vol. 296, 184-186.
• Ascenzi P, Fruttero R, Amiconi G, Pugliese L, Bolognesi M, Coletta M, Onesti S, Guarneri M, Menegatti E (1992) Inhibition of human alpha-, beta- and gamma-thrombin by mono-, bis-, tris- and tetra-benzamidine structures: thermodynamic study. J Enz Inhib. Vol. 6, 131-139.
• Ascenzi P, Coletta M, Desideri A, Petruzzelli R, Polizio F, Bolognesi M, Condò SG, Giardina B (1992) Spectroscopic properties of the nitric oxide derivative of ferrous man, horse, and ruminant hemoglobins: a comparative study. J Inorg Biochem. Vol. 45, 31-37.
• Condò SG, Coletta M, Cicchetti R, Argentin G, Guerrieri P, Marini S, el-Sherbini S, Giardina B (1992) The ‘natural’ hybrid haemoglobin from mule. Interrelationships with its parent haemoglobins from horse and donkey. Biochem J. Vol. 282, 595-599.
• Ascenzi P, Amiconi G, Coletta M, Lupidi G, Menegatti E, Onesti S, Bolognesi M (1992) Binding of hirudin to human alpha, beta and gamma-thrombin. A comparative kinetic and thermodynamic study. J Mol Biol. Vol. 225, 177-184.
• Catarino T, Coletta M, LeGall J, Xavier AV (1991) Kinetic study of the reduction mechanism for Desulfovibrio gigas cytochrome c3. Eur J Biochem. Vol. 202, 1107-1113.
• Coletta M, Catarino T, LeGall J, Xavier AV (1991) A thermodynamic model for the cooperative functional properties of the tetraheme cytochrome c3 from Desulfovibrio gigas. Eur J Biochem. Vol. 202, 1101-1106.
• Hofrichter J, Henry ER, Szabo A, Murray LP, Ansari A, Jones CM, Coletta M, Falcioni G, Brunori M, Eaton WA (1991) Dynamics of the quaternary conformational change in trout hemoglobin. Biochemistry. Vol. 30, 6583-6598.
• Coletta M, Geraci G (1991) Observation of a stable intermediate form in the reaction of human hemoglobin with carbon monoxide. Eur J Biochem. Vol. 196, 569-573.
• Congiu Castellano A, Della Longa S, Bianconi A, Barteri M, Burattini E, Ascenzi P, Coletta M, Cantucci R, Amiconi G (1991) Influence of allosteric effectors on the heme conformation of dromedary ferrous nitrosylhemoglobin detected by XANES spectroscopy.. Biochim Biophys Acta. Vol. 1080, 119-125.
• Miller MA, Mauro JM, Smulevich G, Coletta M, Kraut J, Traylor TG (1990) CO dissociation in cytochrome c peroxidase: site-directed mutagenesis shows that distal Arg 48 influences CO dissociation rates. Biochemistry. Vol. 29, 9978-9988.
• Coletta M, Ascenzi P, Amiconi G, Bolognesi M, Guarneri M, Menegatti E (1990) Bovine trypsinogen activation. A thermodynamic study.. Biophys Chem. Vol. 37, 355-362.
• Ascenzi P, Coletta M, Amiconi G, Bolognesi M, Menegatti E, Guarneri M (1990) Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor) to human and bovine factor Xa. A thermodynamic study. Biol Chem Hoppe-Seyler. Vol. 371, 389-393.
• Ascenzi P, Coletta M, Desideri A, Polizio F, Condò SG, Giardina B (1990) Effect of inositol hexakisphosphate on the spectroscopic properties of the nitric oxide derivative of ferrous horse and bovine hemoglobin. J Inorg Biochem. Vol. 40, 157-162.
• Coletta M, Boffi A, Ascenzi P, Brunori M, Chiancone E (1990) A novel mechanism of heme-heme interaction in the homodimeric hemoglobin from Scapharca inaequivalvis as manifested upon cleavage of the proximal Fe-N epsilon bond at low pH. J Biol Chem. Vol. 265, 4828-4830.
• Coletta M, Ascenzi P, Bravin L, Amiconi G, Bolognesi M, Guarneri M, Menegatti E (1990) Thermodynamic modeling of internal equilibria involved in the activation of trypsinogen. J Biomol Struct Dynam. Vol. 7, 959-972.
• Miller MA, Coletta M, Mauro JM, Putnam LD, Farnum MF, Kraut J, Traylor TG (1990) CO recombination in cytochrome c peroxidase: effect of the local heme environment on CO binding explored through site-directed mutagenesis. Biochemistry. Vol. 29, 1777-1791.
• Amiconi G, Santucci R, Coletta M, Castellano AC, Giovannelli A, Dell’Ariccia M, Della Longa S, Barteri M, Burattini E, Bianconi A (1989) Influence of globin structure on the heme in dromedari carbonmonoxyhemoglobin. Biochemistry. Vol. 28, 8547-8553.
• Ascenzi P, Brunori M, Coletta M, Desideri A (1989) pH effects on the haem iron co-ordination state in the nitric oxide and deoxy derivatives of ferrous horseradish peroxidase and cytochrome c peroxidase. Biochem J. Vol. 258, 473-478.
• Brunori M, Coletta M, Bellelli A, Evangelista V, Benedetti PA, Brumen M (1989) Microspectroscopy of red blood cells. Haematologia. Vol. 22, 69-78.
• Coletta M, Ascenzi P, Brunori M (1988) Kinetic evidence for a role of heme geometry on the modulation of carbon monoxide reactivity in human hemoglobin. J Biol Chem. Vol. 263, 18286-18289.
• Bellelli A, Benedetti PL, Coletta M, Ippoliti R, Brunori M (1988) Human erythrocytes cross-linked with glutaraldehyde general properties and significance as a blood substitute. Biochem Biophys Res Commun. Vol. 156, 970-977.
• Ascenzi P, Coletta M, Amiconi G, de Cristofaro R, Bolognesi M, Guarneri M, Menegatti E (1988) Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human alpha-, beta- and gamma-thrombin; a kinetic and thermodynamic study. Biochim Biophys Acta. Vol. 956, 156-161.
• Coletta M, Amiconi G, Bellelli A, Bertollini A, Carsky J, Castagnola M, Condò S, Brunori M (1988) Alteration of T-state binding properties of naturally glycated hemoglobin, HbA1c. J Mol Biol. Vol. 203, 233-239.
• Coletta M, Alayash AI, Wilson MT, Benedetti PA, Evangelista V, Brunori M (1988) Single cell microspectroscopy reveals that erythrocytes containing hemoglobin S retain a ‘memory’ of previous sickling cycles. FEBS Lett. Vol. 236, 127-131.
• Ascenzi P, Coletta M, Amiconi G, Bolognesi M, Guarneri M, Menegatti E (1988) Zymogen activation: effect of peptides sequentially related to the bovine beta-trypsin N-terminus on Kazal inhibitor and benzamidine binding to bovine trypsinogen. J Mol Recogn. Vol. 1, 130-137.
• Ascenzi P, Desideri A, Amiconi G, Bertollini A, Bolognesi M, Castagnola M, Coletta M, Brunori M (1988) Effect of inositol hexakisphosphate on the spectroscopic properties of the nitric oxide derivative of ferrous naturally glycated human hemoglobin HbA1c. J Inorg Biochem. Vol. 34, 19-24.
• Spagnuolo C, Rinelli P, Coletta M, Vecchini P, Chiancone E, Ascoli F (1988) Oxidation reaction of Scapharca inaequivalvis hemoglobins with nitrite. Biochim. Biophys Acta. Vol. 956, 119-126.
• Coletta M, Santucci R, Focesi A Jr, Ascoli F, Brunori M (1987) Redox properties of components I and IV of trout hemoglobins: kinetic and potentiometric studies. Biochim Biophys Acta. Vol. 915, 415-419.
• Spagnuolo C, Rinelli P, Coletta M, Chiancone E, Ascoli F (1987) Oxidation reaction of human oxyhemoglobin with nitrite: a reexamination. Biochim Biophys Acta. Vol. 911, 59-65.
• Coletta M, Brumen M, Giardina B, Benedetti PA, Brunori M (1987) A microspectroscopic analysis of ligand binding in single erythrocyte. Biomed Biochim Acta. Vol. 46, S108-S112.
• Coletta M, Falcioni G, Concetti A, Ascoli F, Brunori M (1986) Ligand-dependent behavior of the hemoglobin from the ascarid Parascaris equorum. Biochim Biophys Acta. Vol. 870, 169-175.
• Coletta M, Ascoli F, Brunori M, Traylor TG (1986) pH dependence of carbon monoxide binding to ferrous horseradish peroxidase. J Biol Chem. Vol. 261, 9811-9814.
• Brunori M, Coletta M, Di Cera E (1986) A cooperative model for ligand binding to biological macromolecules as applied to oxygen carriers. Biophys Chem. Vol. 23, 215-222.
• Zolla L, Coletta M, di Cera E, Giardina B, Kuiper H, Brunori M (1986) Discrimination of tertiary and quaternary Bohr effect in the O2 binding of Helix pomatia beta-hemocyanin. Biophys Chem. Vol. 24, 319-325.
• Gill SJ, Robert CH, Coletta M, Di Cera E, Brunori M (1986) Cooperative free energies for nested allosteric models as applied to human hemoglobin. Biophys J. Vol. 50, 747-752.
• Coletta M, Brittain T, Brunori M (1986) Evidence for a kinetic heterogeneity in ligand binding to R-state haemoglobin Kempsey [Asp-G1(99) beta—-Asn]. Biochem J. Vol. 238, 353-357.
• Ascenzi P, Coletta M, Desideri A, Brunori M (1985) pH-induced cleavage of the proximal histidine to iron bond in the nitric oxide derivative of ferrous monomeric hemoproteins and of the “chelated” protoheme model compound. Biochim Biophys Acta. Vol. 829, 299-302.
• Ascenzi P, Brunori M, Coletta M, Traylor TG (1985) Iron atom displacement and ligand reactivity in ferrous heme proteins: effects of proximal bond. In: Clementi E; Corongiu G; Sarma MH; Sarma RH. Structure and Motion:Nucleic acids and proteins. p. 331-337.
• Brunori M, Coletta M, Giardina B (1985) Oxygen carrier proteins. In: Harrison PM. Metalloproteins: Metal proteins with non-redox roles. p. 263-331.
• Coletta M, Ascenzi P, Traylor TG, Brunori M (1985) Kinetics of carbon monoxide binding to monomeric hemoproteins. Role of the proximal histidine. J Biol Chem. Vol. 260, 4151-4155.
• Amiconi G, Bertollini A, Bellelli A, Coletta M, Condò SG, Brunori M (1985) Evidence for two oxygen-linked binding sites for polyanions in dromedary hemoglobin. Eur J Biochem. Vol. 150, 387-393.
• Coletta M, Giardina B, Amiconi G, Gualtieri P, Benedetti PA, Brunori M (1985) Kinetics of the reaction of intraerythrocytic haemoglobin by single cell microspectroscopy: effect of shape and osmolarity. FEBS Lett. Vol. 190, 217-220.
• Petruzzelli R, Barra D, Goffredo BM, Bossa F, Coletta M, Brunori M (1984) Amino-acid sequence of beta-chain of hemoglobin IV from trout (Salmo irideus). Biochim Biophys Acta. Vol. 789, 69-73.
• Traylor TG, Deardurff LA, Coletta M, Ascenzi P, Antonini E, Brunori M (1983) Reactivity of ferrous heme proteins at low pH. J Biol Chem. Vol. 258, 12147-12148.
• Giardina B, Falcioni G, Coletta M, Brunori M (1983) The reaction of trout hemoglobins with isocyanides. Eur J Biochem. Vol. 135, 171-174.
• Coletta M, Hofrichter J, Ferrone FA, Eaton WA (1982) Kinetics of sickle haemoglobin polymerization in single red cells. Nature. Vol. 300, 194-197.
• Colosimo A, Coletta M, Falcioni G, Giardina B, Gill SJ, Brunori M (1981) Thermodynamics of oxygen binding to trout haemoglobin I and its oxidation intermediates. J Mol Biol. Vol. 160, 531-543.
• Brunori M, Coletta M, Ilgenfritz G (1981) Temperature jump of hemoglobin. Meth. Enzymol. Vol. 76, 681-704.
• Kuiper HA, Coletta M, Zolla L, Chiancone E, Brunori M (1980) Root effect of Panulirus interruptus hemocyanin. Biochim Biophys Acta. Vol. 626, 412-416.
• Giardina B, Giacometti GM, Coletta M, Brunori M, Giacometti G, Rigatti G (1978) A comparative approach to protein- and ligand-dependence of the Root effect for fish haemoglobins. Biochem J. Vol. 175, 407-412.
• Brunori M, Coletta M, Giardina B, Wyman J (1978) A macromolecular transducer as illustrated by trout hemoglobin IV. Proc Natl Acad Sci USA. Vol. 75, 4310-4312.
• Bossa F, Barra D, Coletta M, Martini F, Liverzani A, Petruzzelli R, Bonaventura J, Brunori M (1976) Primary structure of hemoglobins from trout (Salmo irideus).partial determination of amino acid sequence of Hb trout IV. FEBS Lett. Vol. 64, 76-80.

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